Evidence map›Paper›PMID 34281206›Full record

ReviewInternational journal of molecular sciences2021

Basic Helix-Loop-Helix (bHLH) Transcription Factors Regulate a Wide Range of Functions in Arabidopsis.

Yaqi Hao, Xiumei Zong, Pan Ren, Yuqi Qian, Aigen Fu

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 1 pooled it
45.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 1 synthesis or guideline pooled it, 288 citations in OpenAlex.

  1. Pooled it
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  4. Review
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  6. Article
  7. Article
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  13. The Maize ZmbHLH118 Transcription Factor Regulates Vacuolar Nitrate Loading by the NOAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  14. Functional Analysis ofPlants (Basel, Switzerland) · 2026
    Article
  15. Article
  16. Review
  17. Article
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  20. Article

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yaqi HaoChinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Xiumei ZongChinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Pan RenChinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Yuqi QianChinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Aigen FuChinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University, China P.R. 229 North Taibai Road, Xi'an, Shaanxi 710069, China.
Northwest University · CN

Funding

National Natural Science Foundation of China 31300204Shaanxi Provincial Science and Technology Department 2019JQ-326
6 · The paper itself

Abstract

The basic helix-loop-helix (bHLH) transcription factor family is one of the largest transcription factor gene families in Arabidopsis thaliana, and contains a bHLH motif that is highly conserved throughout eukaryotic organisms. Members of this family have two conserved motifs, a basic DNA binding region and a helix-loop-helix (HLH) region. These proteins containing bHLH domain usually act as homo- or heterodimers to regulate the expression of their target genes, which are involved in many physiological processes and have a broad range of functions in biosynthesis, metabolism and transduction of plant hormones. Although there are a number of articles on different aspects to provide detailed information on this family in plants, an overall summary is not available. In this review, we summarize various aspects of related studies that provide an overview of insights into the pleiotropic regulatory roles of these transcription factors in plant growth and development, stress response, biochemical functions and the web of signaling networks. We then provide an overview of the functional profile of the bHLH family and the regulatory mechanisms of other proteins.

Indexed as

Amino Acid SequenceArabidopsisArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsGene ExpressionGenome, PlantHelix-Loop-Helix MotifsMultigene FamilyPhylogenyPlant ProteinsSequence Analysis, DNATranscription FactorsArabidopsis ProteinsBasic Helix-Loop-Helix ProteinsPlant ProteinsTranscription Factorsbasic helix-loop-helix (bHLH)cross-talkplant growth and developmenttranscription factor

Identifiers

PMID34281206
PMCPMC8267941
OpenAlexW3175702406

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.