ReviewInternational journal of molecular sciences2021
Antimicrobial Activity of Curcumin in Nanoformulations: A Comprehensive Review.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The potential application of natural products in cutaneous wound healing: A review of preclinical evidence.Frontiers in pharmacology · 2022Pooled it
- A Systematic Review on Nanoencapsulation Natural Antimicrobials in Foods: In Vitro versus In Situ Evaluation, Mechanisms of Action and Implications on Physical-Chemical Quality.International journal of molecular sciences · 2021Pooled it
- Sustainable Chitosan-Based Nanoparticles for Curcumin Delivery: Assessment of Chemical Integrity and Antibacterial Activity AgainstACS omega · 2026Article
- A Curcumin-Loaded Liposomal Photodynamic Nanosystem for Effective Treatment of Bacterial Wound Infections.Pharmaceutics · 2026Article
- Ethnobotany-guided exploration of plant-derived photosensitizer candidates for photodynamic therapy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- A Critical Synthesis of Natural Photosensitizers in Photodynamic Food Preservation Covering Mechanisms, Matrix-Specific Applications, and Translational Barriers.Comprehensive reviews in food science and food safety · 2026Review
- Strategies to Enhance the Efficacy and Clinical Translation of Antimicrobial Photodynamic Therapy.Antibiotics (Basel, Switzerland) · 2026Review
- Time-dependent effect of nanoparticle-based intracanal medicament on root dentin microhardness and their antibacterial efficacy againstJournal of conservative dentistry and endodontics · 2026Article
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- Mechanisms of Bacterial Resistance and Innovative Strategies to Overcome Antimicrobial Resistance.Antibiotics (Basel, Switzerland) · 2026Review
- Production of Antimicrobial and Antioxidant Metabolites byFoods (Basel, Switzerland) · 2026Article
- He-Ne laser irradiation enhances curcuminoid content inFrontiers in nutrition · 2026Article
- Comparative Antimicrobial and Oxidative Damage of Indocyanine Green, Methylene Blue, and Curcumin on Dual-Species Biofilms ofInternational journal of molecular sciences · 2025Article
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- Triaxial Electrospun Nanofiber Membranes for Prolonged Curcumin Release in Dental Applications: Drug Release and Biological Properties.Molecules (Basel, Switzerland) · 2025Article
- Natural Biomolecules and Light: Antimicrobial Photodynamic Strategies in the Fight Against Antibiotic Resistance.International journal of molecular sciences · 2025Review
- Bioimaging and Sensing Properties of Curcumin and Derivatives.International journal of molecular sciences · 2025Review
- Blue-Light Photoactivated Curcumin-Loaded Chitosan Nanoparticles Prepared by Nanoprecipitation and Ionic Gelation: A Promising Approach for Antimicrobial Photodynamic Inactivation.ACS applied bio materials · 2025Article
- Curcumin Reverses Antibiotic Resistance and Downregulates Shiga Toxin Expression in EnterohemorrhagicDiseases (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Curcumin (CUR) is a natural substance extracted from turmeric that has antimicrobial properties. Due to its ability to absorb light in the blue spectrum, CUR is also used as a photosensitizer (PS) in antimicrobial Photodynamic Therapy (aPDT). However, CUR is hydrophobic, unstable in solutions, and has low bioavailability, which hinders its clinical use. To circumvent these drawbacks, drug delivery systems (DDSs) have been used. In this review, we summarize the DDSs used to carry CUR and their antimicrobial effect against viruses, bacteria, and fungi, including drug-resistant strains and emergent pathogens such as SARS-CoV-2. The reviewed DDSs include colloidal (micelles, liposomes, nanoemulsions, cyclodextrins, chitosan, and other polymeric nanoparticles), metallic, and mesoporous particles, as well as graphene, quantum dots, and hybrid nanosystems such as films and hydrogels. Free (non-encapsulated) CUR and CUR loaded in DDSs have a broad-spectrum antimicrobial action when used alone or as a PS in aPDT. They also show low cytotoxicity, in vivo biocompatibility, and improved wound healing. Although there are several in vitro and some in vivo investigations describing the nanotechnological aspects and the potential antimicrobial application of CUR-loaded DDSs, clinical trials are not reported and further studies should translate this evidence to the clinical scenarios of infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.