Evidence map›Paper›PMID 34281165›Full record

ArticleInternational journal of molecular sciences2021

Novel

Ilse Van Gucht, Alice Krebsova, Birgitte Rode Diness, Steven Laga, Dave Adlam, Marlies Kempers, Nilesh J Samani, Tom R Webb, Ania A Baranowska, Lotte Van Den Heuvel and 9 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Genetic Causes of Thoracic Aortic Aneurysm: A Review.Methodist DeBakey cardiovascular journal · 2026
    Review
  5. Sex differences and role of lysyl oxidase-like 2 in angiotensin II-induced hypertension in mice.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 5 countries.

Ilse Van GuchtCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Alice KrebsovaDepartment of Cardiology, IKEM, Praha 4, 14021 Prague, Czech Republic.ORCID 0000-0001-8319-1460
Birgitte Rode DinessDepartment of Clinical Genetics, Copenhagen University Hospital, 2100 Copenhagen, Denmark.
Steven LagaDepartment of Cardiac Surgery, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Dave AdlamAcute and interventional Cardiology, University of Leicester, Leicester LE3 9QP, UK.
Marlies KempersDepartment of Human Genetics, Radboud University Medical Center, 6525 Nijmegen, The Netherlands.
Nilesh J SamaniAcute and interventional Cardiology, University of Leicester, Leicester LE3 9QP, UK.
Tom R WebbAcute and interventional Cardiology, University of Leicester, Leicester LE3 9QP, UK.
Ania A BaranowskaAcute and interventional Cardiology, University of Leicester, Leicester LE3 9QP, UK.ORCID 0000-0003-0827-6792
Lotte Van Den HeuvelCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Melanie PerikCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Ilse LuyckxCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.ORCID 0000-0002-9668-0535
Nils PeetersCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Pavel VotypkaDepartment of Biology and Medical Genetics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Praha 5, 15006 Prague, Czech Republic.
Milan MacekDepartment of Biology and Medical Genetics, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Praha 5, 15006 Prague, Czech Republic.ORCID 0000-0002-5173-5280
Josephina MeesterCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.ORCID 0000-0001-8516-5856
Lut Van LaerCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Aline VerstraetenCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.
Bart L LoeysCenter of Medical Genetics, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, 2650 Antwerp, Belgium.ORCID 0000-0003-3703-9518
University of Antwerp · BEUniversity of Leicester · GBCharles University · CZRadboud University Nijmegen · NLCopenhagen University Hospital · DKInstitute of Clinical and Experimental Medicine · CZ

Funding

Dutch Heart Foundation 2013T093European 398 Reference Network on rare multisystemic vascular disorders 769036European Research Council ERC-COG-2017-771945)Fonds Wetenschappelijk Onderzoek 12X8520NFonds Wetenschappelijk Onderzoek 1S70419NFonds Wetenschappelijk Onderzoek 1S81820NFonds Wetenschappelijk Onderzoek G040221N,Fonds Wetenschappelijk Onderzoek G042321NFonds Wetenschappelijk Onderzoek G044720NUniversiteit Antwerpen FFB190208
6 · The paper itself

Abstract

Thoracic aortic aneurysm and dissection (TAAD) is a major cause of cardiovascular morbidity and mortality. Loss-of-function variants in

Indexed as

AdultAortaAortic Aneurysm, ThoracicAortic DissectionArteriesConnective TissueConnective Tissue DiseasesFemaleGenetic Predisposition to DiseaseHumansMaleMiddle AgedMutationPedigreeProtein-Lysine 6-OxidaseLOX protein, humanProtein-Lysine 6-OxidaseECMLDSLOXMFSTAAD

Identifiers

PMID34281165
PMCPMC8269155
OpenAlexW3175304722

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.