ReviewInternational journal of molecular sciences2021
Chronic Orofacial Pain: Models, Mechanisms, and Genetic and Related Environmental Influences.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
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Who cites it
60 citing papers in PubMed.
- Application of a cancer pain belief modification program for patients with oral cancer in China: a mixed methods study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- The Interaction Between the Central Nervous System and Dental Tissues: Hypothetical Dental Interoception Inferred From Skeletal Interoception.Journal of oral rehabilitation · 2026Review
- Beyond Disease Categories: The Adaptive Hierarchical Domain Network (AHDN) for Precision Phenotyping and Personalized Management of Chronic Orofacial Pain.Clinics and practice · 2026Article
- Chronic ocular pain is associated with smaller selective hippocampal subfield in highly symptomatic patients.The journal of pain · 2026Article
- The Pathophysiological Mechanisms of Glia in Animal Models of Chronic Orofacial Pain: A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Orofacial pain and dementia: a brief narrative review of associations, putative mechanisms, and relevant clinical considerations.Odontology · 2026Review
- Impact of climatic factors on trigeminal neuralgia and facial neuropathy in primary care during a fourteen-year time-series study.Scientific reports · 2026Article
- Exploring Cognitive, Behavioral, and Psychological Dimensions in Persistent Idiopathic Facial Pain and Other Chronic Orofacial Pain Conditions.Brain and behavior · 2026Article
- Coping strategies used by individuals with chronic orofacial pain: A qualitative study.Journal of health psychology · 2026Article
- Acute Intravenous Astaxanthin Administration Modulates Hyperexcitability in Rat Nociceptive Secondary Sensory Neurons Induced by Inflammation.Marine drugs · 2026Article
- The past, present, and future of temporomandibular disorders in predoctoral curriculum: historical perspectives and what comes next.Journal of oral & facial pain and headache · 2026Review
- Editorial: Data driven analytics in orofacial pain.Frontiers in dental medicine · 2026Article
- Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity.The journal of headache and pain · 2025Article
- Exploring Pain Phenotyping in Cervicogenic Headache Management.Current pain and headache reports · 2025Review
- Applicability of the theory of pain-sensorimotor interactions to orofacial pain and sensorimotor behavior, and implications for orofacial pain research and management.Journal of oral & facial pain and headache · 2025Review
- Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.The journal of pain · 2025Review
- Myricetin Attenuates Hyperexcitability of Trigeminal Nociceptive Second-Order Neurons in Inflammatory Hyperalgesia: Celecoxib-like Effects.Molecules (Basel, Switzerland) · 2025Article
- Astaxanthin Alleviates Inflammatory Mechanical Hyperalgesia by Reducing Hyperexcitability of Trigeminal Nociceptive Secondary Neurons: Potential as an NSAID Alternative.Molecules (Basel, Switzerland) · 2025Article
- Chronic orofacial pain and psychological distress: findings from a multidisciplinary university clinic.Journal of oral & facial pain and headache · 2025Article
- Neurophysiological Basis of Short-Chain Fatty Acid Action in Pain Modulation: Therapeutic Implications.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic orofacial pain conditions can be particularly difficult to diagnose and treat because of their complexity and limited understanding of the mechanisms underlying their aetiology and pathogenesis. Furthermore, there is considerable variability between individuals in their susceptibility to risk factors predisposing them to the development and maintenance of chronic pain as well as in their expression of chronic pain features such as allodynia, hyperalgesia and extraterritorial sensory spread. The variability suggests that genetic as well as environmental factors may contribute to the development and maintenance of chronic orofacial pain. This article reviews these features of chronic orofacial pain, and outlines findings from studies in animal models of the behavioural characteristics and underlying mechanisms related to the development and maintenance of chronic orofacial pain and trigeminal neuropathic pain in particular. The review also considers the role of environmental and especially genetic factors in these models, focussing on findings of differences between animal strains in the features and underlying mechanisms of chronic pain. These findings are not only relevant to understanding underlying mechanisms and the variability between patients in the development, expression and maintenance of chronic orofacial pain, but also underscore the importance for considering the strain of the animal to model and explore chronic orofacial pain processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.