Evidence map›Paper›PMID 34281008›Full record

ArticleInternational journal of environmental research and public health2021

A Scoping Review of the Association of Social Disadvantage and Cerebrovascular Disease Confirmed by Neuroimaging and Neuropathology.

Sarah A Keller, Kellia J Hansmann, W Ryan Powell, Barbara B Bendlin, Amy J H Kind

Open access · goldAbstract readScoping Review
In one paragraph

Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Life Course Assessment of Area-Based Social Disadvantage: A Systematic Review.International journal of environmental research and public health · 2023
    Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah A KellerDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0003-1356-1803
Kellia J HansmannDepartment of Family Medicine and Community Health, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.ORCID 0000-0002-3371-0311
W Ryan PowellCenter for Health Disparities Research, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.
Barbara B BendlinCenter for Health Disparities Research, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.
Amy J H KindCenter for Health Disparities Research, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.
University of Wisconsin–Madison · USUnited States Department of Veterans Affairs · US

Funding

The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5M
White matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3M
Neighborhood Socioeconomic Contextual Disadvantage and Alzheimer's DiseaseRF1AG057784 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA, KIND, AMY J. · 2017 to 2017
$3.8M
HRSA HHS T32HP10010NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG070883NIA NIH HHS RF1 AG057784NIH HHS P30AG062715NIH HHS R01AG070883NIH HHS RF1AG057784
6 · The paper itself

Abstract

Social disadvantage-a state of low-income, limited education, poor living conditions, or limited social support-mediates chronic health conditions, including cerebrovascular disease. Social disadvantage is a key component in several health impact frameworks, providing explanations for how individual-level factors interact with interpersonal and environmental factors to create health disparities. Understanding the association between social disadvantage and vascular neuropathology, brain lesions identified by neuroimaging and autopsy, could provide insight into how one's social context interacts with biological processes to produce disease. The goal of this scoping review was to evaluate the scientific literature on the relationship between social disadvantage and cerebrovascular disease, confirmed through assessment of vascular neuropathology. We reviewed 4049 titles and abstracts returned from our search and included records for full-text review that evaluated a measure of social disadvantage as an exposure variable and cerebrovascular disease, confirmed through assessment of vascular neuropathology, as an outcome measure. We extracted exposures and outcomes from 20 articles meeting the criteria after full-text review, and described the study findings and populations sampled. An improved understanding of the link between social factors and cerebrovascular disease will be an important step in moving the field closer to addressing the fundamental causes of disease and towards more equitable brain health.

Indexed as

Cerebrovascular DisordersNeuroimagingBrainHumansPopulation GroupsSocial Environmentcerebrovascular diseasedisparitieseducationethnicityneuropathologyracesocial disadvantagesocioeconomic status

Identifiers

PMID34281008
PMCPMC8297247
OpenAlexW3184527499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.