Evidence map›Paper›PMID 34280910›Full record

ArticlePhysics in medicine and biology2021

The relation between microdosimetry and induction of direct damage to DNA by alpha particles.

Alejandro Bertolet, José Ramos-Méndez, Harald Paganetti, Jan Schuemann

Open access · greenAbstract read
In one paragraph

Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Alejandro BertoletDepartment of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, United States of America.ORCID 0000-0002-9890-693X
José Ramos-MéndezDepartment of Radiation Oncology, University of California San Francisco, United States of America.ORCID 0000-0002-8106-5142
Harald PaganettiDepartment of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, United States of America.ORCID 0000-0002-6257-2413
Jan SchuemannDepartment of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, United States of America.ORCID 0000-0002-7554-8818
Harvard University · USUniversity of California, San Francisco · US

Funding

TOPAS - nBio, a Monte Carlo tool for radiation biology researchR01CA187003 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SCHUEMANN, JAN PATRICK OSCAR · 2015 to 2024
$4.8M
The TOPAS Tool for Particle Simulation, a Monte Carlo Simulation Tool for Physics, Biology and Clinical ResearchU24CA215123 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FADDEGON, BRUCE · 2018 to 2022
$4.2M
Radiation dosimetry for alpha-particle radiopharmaceutical therapy and application to pediatric neuroblastomaK99CA267560 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BERTOLET REINA, ALEJANDRO · 2022 to 2023
$188k
NCI NIH HHS K99 CA267560NCI NIH HHS R01 CA187003NCI NIH HHS U24 CA215123
6 · The paper itself

Abstract

In radiopharmaceutical treatments

Indexed as

Alpha ParticlesDNADNA DamageMonte Carlo MethodRadiation, IonizingDNAalpha particlesDNA direct damagemicrodosimetryTOPASTOPAS-nBio

Identifiers

PMID34280910
PMCPMC8483580
OpenAlexW3183143468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.