Evidence map›Paper›PMID 34280739›Full record

ReviewDevelopmental cognitive neuroscience2021

EEG/ERP as a pragmatic method to expand the reach of infant-toddler neuroimaging in HBCD: Promises and challenges.

Elizabeth S Norton, Leigha A MacNeill, Emily M Harriott, Norrina Allen, Sheila Krogh-Jespersen, Christopher D Smyser, Cynthia E Rogers, Tara A Smyser, Joan Luby, Lauren Wakschlag

Open access · goldAbstract readReview
In one paragraph

Review in Developmental cognitive neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Pooled it
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  5. Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Elizabeth S NortonRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, Northwestern University, United States; Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, United States; Institute for Innovations in Developmental Sciences, Northwestern University, United States. Electronic address: enorton@northwestern.edu.
Leigha A MacNeillDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, United States; Institute for Innovations in Developmental Sciences, Northwestern University, United States.
Emily M HarriottDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, United States.
Norrina AllenInstitute for Innovations in Developmental Sciences, Northwestern University, United States; Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, United States.
Sheila Krogh-JespersenDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, United States; Institute for Innovations in Developmental Sciences, Northwestern University, United States.
Christopher D SmyserDepartments of Neurology, Pediatrics, and Radiology, Washington University School of Medicine, United States; Department of Psychiatry, Washington University School of Medicine, United States.
Cynthia E RogersDepartment of Psychiatry, Washington University School of Medicine, United States.
Tara A SmyserDepartment of Psychiatry, Washington University School of Medicine, United States.
Joan LubyDepartment of Psychiatry, Washington University School of Medicine, United States.
Lauren WakschlagDepartment of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, United States; Institute for Innovations in Developmental Sciences, Northwestern University, United States.
Northwestern University · USUniversity of Washington · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
The Healthy Brain and Child Development National Consortium Administrative CoreU24DA055325 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHRISTINA CHAMBERS, CHARLES Alexander NELSON · 2021 to 2026
$40.8M
Early Life Adversity, Biological Embedding, and Risk for Developmental Precursors of Mental DisordersR01MH113883 · NIMH · WASHINGTON UNIVERSITY · PI JOAN L. LUBY, Christopher Daniel Smyser · 2018 to 2026
$20.6M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Optimizing prediction of preschool psychopathology from brain: behavior markers of emotion dysregulation from birth: A computational, developmental cognitive neuroscience approachR01MH121877 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LUBY, JOAN L., ROGERS, CYNTHIA ELISE · 2020 to 2024
$8.2M
Generating an Earlier Science of When to Worry: A Neurodevelopmental, Transactional Approach to Characterizing Irritability Patterns Beginning in InfancyR01MH107652 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2016 to 2021
$4.0M
The When to Worry about Language Study (W2W-L): Joint consideration of developmental patterning and neural substrates for enhancing earlyidentification of language impairmentR01DC016273 · NIDCD · NORTHWESTERN UNIVERSITY · PI NORTON, ELIZABETH SPENCER, WAKSCHLAG, LAUREN S · 2018 to 2022
$3.6M
2/2 Optimizing access, engagement and assessment to elucidate prenatal influences on neurodevelopment: The Brains Begin Before Birth(B4 ) Midwest ConsortiumR34DA050266 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WAKSCHLAG, LAUREN S · 2019 to 2020
$687k
Parent-toddler EEG neural synchrony as a window into social communication deficits in autismR21DC017210 · NIDCD · NORTHWESTERN UNIVERSITY · PI NORTON, ELIZABETH SPENCER · 2018 to 2019
$426k
NCATS NIH HHS UL1 TR001422NICHD NIH HHS P50 HD103525NIDA NIH HHS R34 DA050266NIDA NIH HHS U24 DA055325NIDCD NIH HHS R01 DC016273NIDCD NIH HHS R21 DC017210NIMH NIH HHS R01 MH107652NIMH NIH HHS R01 MH113883NIMH NIH HHS R01 MH121877
6 · The paper itself

Abstract

Though electrophysiological measures (EEG and ERP) offer complementary information to MRI and a variety of advantages for studying infants and young children, these measures have not yet been included in large cohort studies of neurodevelopment. This review summarizes the types of EEG and ERP measures that could be used in the HEALthy Brain and Cognitive Development (HBCD) study, and the promises and challenges in doing so. First, we provide brief overview of the use of EEG/ERP for studying the developing brain and discuss exemplar findings, using resting or baseline EEG measures as well as the ERP mismatch negativity (MMN) as exemplars. We then discuss the promises of EEG/ERP such as feasibility, while balancing challenges such as ensuring good signal quality in diverse children with different hair types. We then describe an ongoing multi-site EEG data harmonization from our groups. We discuss the process of alignment and provide preliminary usability data for both resting state EEG data and auditory ERP MMN in diverse samples including over 300 infants and toddlers. Finally, we provide recommendations and considerations for the HBCD study and other studies of neurodevelopment.

Indexed as

BrainElectroencephalographyChild, PreschoolCognitionHumansInfantLongitudinal StudiesNeuroimagingEEGERPHBCDMismatch negativityNeurodevelopment

Identifiers

PMID34280739
PMCPMC8318873
OpenAlexW3184360937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.