Evidence map›Paper›PMID 34280657›Full record

ArticleJournal of critical care2021

Evolution of practice patterns in the management of acute respiratory distress syndrome: A secondary analysis of two successive randomized controlled trials.

Kate C Tatham, Niall D Ferguson, Qi Zhou, Lori Hand, Peggy Austin, Ravi Taneja, Alejandro C Arroliga, Juan F Sanchez, Edgar J Jimenez, Brandon P Staub and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of critical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 13 institutions in 5 countries.

Kate C TathamDepartment of Medicine, Division of Respirology & Critical Care Medicine, University Health Network and Sinai Health System, Toronto, Canada; Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery & Cancer, Imperial College, London, United Kingdom.
Niall D FergusonDepartment of Medicine, Division of Respirology & Critical Care Medicine, University Health Network and Sinai Health System, Toronto, Canada; Interdepartmental Division of Critical Care Medicine, Departments of Medicine and Physiology, Institute for Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Qi ZhouDepartment of Health Research Methods, Evidence, and Impact (HEI), McMaster University Health Sciences Centre, Hamilton, Canada.
Lori HandDepartment of Health Research Methods, Evidence, and Impact (HEI), McMaster University Health Sciences Centre, Hamilton, Canada.
Peggy AustinDepartment of Health Research Methods, Evidence, and Impact (HEI), McMaster University Health Sciences Centre, Hamilton, Canada.
Ravi TanejaUniversity of Western Ontario, Anesthesia, Medicine and Critical Care, London, Canada.
Alejandro C ArroligaDivision of Pulmonary and Critical Care Medicine, Baylor Scott and White Health, Temple, TX, United States; Texas A&M Health Sciences Centre, College of Medicine, Temple, TX, United States.
Juan F SanchezDivision of Pulmonary and Critical Care Medicine, Baylor Scott and White Health, Temple, TX, United States; Texas A&M Health Sciences Centre, College of Medicine, Temple, TX, United States.
Edgar J JimenezDivision of Pulmonary and Critical Care Medicine, Baylor Scott and White Health, Temple, TX, United States; Texas A&M Health Sciences Centre, College of Medicine, Temple, TX, United States.
Brandon P StaubDepartment of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Michelle E KhoSchool of Rehabilitation Science, McMaster University, Hamilton, Canada.
J Guillermo Domínguez-CheritDivision of Critical Care, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", México City, Mexico; School of Medicine, Instituto Tecnologico de Monterrey, Monterrey City, Mexico.
Adam MullalyMain Line Health, Bryn Mawr Hospital, Philadelphia, PA, United States.
Yaseen M ArabiIntensive Care Department, College of Medicine-Riyadh, King Saud bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Maureen O MeadeDepartment of Health Research Methods, Evidence, and Impact (HEI), McMaster University Health Sciences Centre, Hamilton, Canada; Interdepartmental Division of Critical Care, Hamilton Health Sciences, Critical Care, Hamilton, Canada.
Baylor Scott & White Health · USUniversity Health Network · CABryn Mawr Hospital · USCentre College · USHamilton Health Sciences · CAHealth Sciences Centre · CAImpact · CAKing Saud bin Abdulaziz University for Health Sciences · SAMcMaster University · CAMcMaster University Medical Centre · CATecnológico de Monterrey · MXUniversity of Pittsburgh Medical Center · USWestern University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe sought to examine changes in acute respiratory distress syndrome (ARDS) management over a 12-year period of two successive randomized trials.

methodsAnalyses included baseline data, from eligible patients, prior to influence of trial protocols, and daily study data, from randomized patients, of variables not determined by trial protocols. Mixed linear regressions examined changes in practice year-on-year.

resultsA total of 2376 patients met the inclusion criteria. Over the 12-year period, baseline tidal volume index decreased (9.0 to 7.0 ml/kg, p < 0.001), plateau pressures decreased (30.8 to 29.0 cmH

conclusionsClear trends were apparent in tidal volume, airway pressures, ventilator modes, adjuncts and rescue therapies. With the exception of prone positioning, and outside the context of rescue therapy, these trends appear consistent with the evolving literature on ARDS management.

Indexed as

Neuromuscular BlockadeRespiratory Distress SyndromeHumansPositive-Pressure RespirationRandomized Controlled Trials as TopicRespiration, ArtificialTidal VolumeARDSCorticosteroidHigh frequency oscillatory ventilationInhaled nitric oxideMechanical ventilationNeuromuscular blockadePEEPPlateau pressureTidal volumeVolume-controlled ventilation

Identifiers

PMID34280657
PMCPMC8255112
OpenAlexW3178095304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.