Evidence map›Paper›PMID 34280476›Full record

ArticleJournal of clinical epidemiology2021

A cohort study revealed high mortality among people who inject drugs in Hai Phong, Vietnam.

Vu Hai Vinh, Roselyne Vallo, Hoang Thi Giang, Duong Thi Huong, Khuat Thi Hai Oanh, Pham Minh Khue, Nham Thi Tuyet Thanh, Catherine Quillet, Delphine Rapoud, Laurent Michel and 7 more

Open access · bronzeAbstract readComparative Study
In one paragraph

Article in Journal of clinical epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 9 institutions in 3 countries.

Vu Hai VinhDepartment of Infectious and Tropical Diseases, Viet Tiep Hospital, Hai Phong, Vietnam.
Roselyne ValloPathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France.
Hoang Thi GiangHai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam.
Duong Thi HuongHai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam.
Khuat Thi Hai OanhSupporting Community Development Initiatives, Hanoi, Vietnam.
Pham Minh KhueHai Phong University of Medicine and Pharmacy, Hai Phong, Vietnam.
Nham Thi Tuyet ThanhSupporting Community Development Initiatives, Hanoi, Vietnam.
Catherine QuilletPathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France.
Delphine RapoudPathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France.
Laurent MichelPierre Nicole Centre, French Red Cross, CESP/Inserm 1018, Paris, France.
Philippe Van de PerrePathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France.
Jonathan FeelemyerNew-York University, New York.
Jean Pierre MolesPathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France. Electronic address: jean-pierre.moles@inserm.fr.
Amandine CournilPathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France.
Don Des JarlaisNew-York University, New York.
Didier LaureillardPathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France; Department of Infectious Diseases, Caremeau University Hospital, Nîmes, France.
Nicolas NagotPathogenesis and control of chronic infections, University of Montpellier, INSERM, Etablissement Français du Sang, University of Antilles, Montpellier, France. Electronic address: n-nagot@chu-montpellier.fr.
Hai phong University Of Medicine and Pharmacy · VNInserm · FRCenter for Creative Initiatives in Health and Population · VNCentre Hospitalier Universitaire de Montpellier · FRÉtablissement Français du Sang · FRNew York University · USHung Vuong Hospital · VNPathogenesis and Control of Chronic and Emerging InfectionsUniversité de Montpellier · FR

Funding

DRIVE (DRug use and blood-borne Infections in ViEtnam): Combined prevention and care to end the HIV epidemic among people who inject drugs in Haiphong, Viet NamR01DA041978 · NIDA · NEW YORK UNIVERSITY · PI DES JARLAIS, DON C · 2016 to 2020
$4.9M
NIDA NIH HHS R01 DA041978
6 · The paper itself

Abstract

objectiveTo estimate the residual mortality rate among people who inject drugs (PWID) in a Low-Middle Income Countries context where the HIV epidemic has been controlled and methadone coverage is high. STUDY DESIGN AND

settingPWID from Haiphong, Vietnam, were recruited through three annual respondent-driven sampling surveys that fueled two cohorts of PWID with HIV (n = 761) and without HIV (n = 897), with bi-annual follow-up. Presumed causes of death were ascertained from medical records and/or interviews of participants family.

resultsAmong the 1658 participants with a median follow-up of 2 years, 67 and 36 died in the HIV-positive and HIV-negative cohort, respectively, yielding crude mortality rates of 4.3 (95% Confidence interval (CI): 3.3-5.4) per 100 person-years of follow-up (PYFU) and 1.9 (CI: 1.4-2.6) per 100 PYFU. In the HIV-positive cohort, in which 81% of participants had undetectable viral load, the two main causes of death were tuberculosis and HIV-related diseases. In the HIV-negative cohort, the two main causes of death were liver-related diseases and overdose. In a time-dependent multivariable model, "unsuppressed viral load" was associated with increased risk of mortality, whereas "being on methadone" or "being employed" was associated with a lower risk.

conclusionDespite a very successful HIV and methadone program, the mortality remains high among PWID in Vietnam, largely due to curable infectious diseases such as tuberculosis and viral hepatitis.

Indexed as

ComorbidityMortalityAdultCohort StudiesDrug UsersFemaleHIV InfectionsHumansMaleMiddle AgedSubstance Abuse, IntravenousVietnamHIVMortalityPeople who inject drugsTuberculosisViral hepatitis

Identifiers

PMID34280476
PMCPMC10116693
OpenAlexW3185266621

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.