Evidence map›Paper›PMID 34280379›Full record

ArticleJournal of the American College of Radiology : JACR2021

Racial Disparities in Diagnostic Delay Among Women With Breast Cancer.

Jasmine M Miller-Kleinhenz, Lindsay J Collin, Rebecca Seidel, Arthi Reddy, Rebecca Nash, Jeffrey M Switchenko, Lauren E McCullough

Open access · greenAbstract read
In one paragraph

Article in Journal of the American College of Radiology : JACR, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

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  15. Applying a Novel Measure of Community-Level Healthcare Access to Assess Breast Cancer Care Timeliness.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jasmine M Miller-KleinhenzDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia. Electronic address: jmill37@emory.edu.
Lindsay J CollinHuntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
Rebecca SeidelDepartment of Radiology and Imaging Services, Emory University School of Medicine, Atlanta, Georgia.
Arthi ReddyDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia.
Rebecca NashDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia.
Jeffrey M SwitchenkoDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health of Emory University, Atlanta, Georgia.
Lauren E McCulloughDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia.
Emory University · USUniversity of Utah · US

Funding

IRACDA Fellowships in Research and Science Training (FIRST)K12GM000680 · NIGMS · EMORY UNIVERSITY · PI BROWN, LOU ANN S, MCCARTY, NAEL A · 2000 to 2024
$41.2M
NRSA Training CoreTL1TR002540 · NCATS · UNIVERSITY OF UTAH · PI FAGERLIN, ANGELA, FAIRFAX, KEKE CELESTE · 2018 to 2022
$1.6M
Biologic and Patient Variation Affecting Breast Cancer Treatment EfficacyF31CA239566 · NCI · EMORY UNIVERSITY · PI COLLIN, LINDSAY JANE · 2019 to 2020
$53k
NCATS NIH HHS TL1 TR002540NCI NIH HHS F31 CA239566NIGMS NIH HHS K12 GM000680
6 · The paper itself

Abstract

purposeEarly diagnosis is fundamental to reducing breast cancer (BC) mortality, and understanding potential barriers from initial screening to confirmed diagnosis is essential. The aim of this study was to evaluate patient characteristics that contribute to delay in diagnosis of screen-detected cancers and the contribution of delay to tumor characteristics and BC mortality.

methodsThree hundred sixty-two White and 368 Black women were identified who were screened and received subsequent BC diagnoses within Emory Healthcare, a part of Emory University health care system (2010-2014). Multivariable-adjusted logistic regression was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs) associating patient characteristics with delay to diagnostic evaluation (≥30 versus <30 days), delay to biopsy (≥15 versus <15 days), and total delay (≥45 versus <45 days). Additionally, the ORs and 95% CIs associating delay with tumor characteristics and BC mortality were computed.

resultsBlack women and women diagnosed at later stages, with larger tumor sizes, and with triple-negative tumors were more likely to experience ≥45 days to diagnosis. In multivariable-adjusted models, Black women had at least a two-fold increase in the odds of delay to diagnostic evaluation (OR, 1.98; 95% CI, 1.45-2.71), biopsy delays (OR, 2.41; 95% CI, 1.67-3.41), and total delays ≥45 days (OR, 2.22; 95% CI, 1.63-3.02) compared with White women. A 1.6-fold increased odds of BC mortality was observed among women who experienced total delays ≥45 days compared with women without delays in diagnosis (OR, 1.57, 95% CI, 0.96-2.58).

conclusionsThe study demonstrated racial disparities in delays in the diagnostic process for screen-detected malignancies. Total delay in diagnosis was associated with an increase in BC mortality.

Indexed as

Breast NeoplasmsBlack or African AmericanDelayed DiagnosisFemaleHealthcare DisparitiesHumansMass ScreeningRacial GroupsBreast cancerdiagnostic delaymortalityracial disparities

Identifiers

PMID34280379
PMCPMC8492512
OpenAlexW3183727476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.