ArticlePloS one2021
Association of Tdap vaccine guidelines with vaccine uptake during pregnancy.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- The effect of alcohol, tobacco, and other drug use on vaccine acceptance, uptake, and adherence: a systematic review.Alcohol and alcoholism (Oxford, Oxfordshire) · 2024Pooled it
- Interventions to increase vaccination against COVID-19, influenza and pertussis during pregnancy: a systematic review and meta-analysis.Journal of travel medicine · 2023Pooled it
- Improving Influenza Vaccine Uptake in Low- and Lower-Middle-Income Countries: A Synthesis of Interventions and Strategic Recommendations.Open forum infectious diseases · 2026Review
- Tetanus Control in the United States and Global Disaster Settings: Public Health Disparities and Prevention Strategies.Medicina (Kaunas, Lithuania) · 2026Review
- Evaluation of Maternal Immunization Rates in Primary Care: A Retrospective Study From Selected Family Health Centers in İstanbul, Türkiye.International journal of public health · 2026Observational
- Assessment of knowledge and attitudes about vaccination in a population of pregnant women and impact of a training program.Human vaccines & immunotherapeutics · 2025Observational
- Influenza vaccine during pregnancy, recommendations from healthcare providers, and race/ethnicity in the United States.Archives of gynecology and obstetrics · 2024Article
- Routine Vaccination During Pregnancy Among People Living With HIV in the United States.JAMA network open · 2024Article
- Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Predictors of Tdap vaccine acceptance in pregnancy before and after delivery.Therapeutic advances in vaccines and immunotherapy · 2024Article
- A Systematic Review of Behaviour Change Techniques within Interventions to Increase Vaccine Uptake among Ethnic Minority Populations.Vaccines · 2023Review
- Tdap vaccination during pregnancy and risk of chorioamnionitis and related infant outcomes.Vaccine · 2023Observational
- Review
- Tetanus, Diphtheria, and Acellular Pertussis Vaccination Coverage Among Publicly Insured Pregnant Women, U.S., 2016-2019.AJPM focus · 2023Article
- Healthcare workers' attitudes on mandates, incentives, and strategies to improve COVID-19 vaccine uptake: A mixed methods study.Human vaccines & immunotherapeutics · 2022Article
- Transplacental Antibody Transfer of Respiratory Syncytial Virus Specific IgG in Non-Human Primate Mother-Infant Pairs.Pathogens (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIn 2012, recommendations for universal tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination during pregnancy were released. Our objective was to determine if Tdap, influenza, and pneumococcal vaccine uptake during pregnancy changed after the release of the guidelines, and identify factors associated with receiving the Tdap and influenza vaccine after 2012.
methodsWe conducted a retrospective cohort study on pregnant individuals who initiated prenatal care before 20 weeks' gestation between 11/2011-11/2012 ("pre-guideline") and 12/2012-12/2015 ("post-guideline"). Vaccine uptake dates were abstracted from medical records. The pre and post-guideline cohorts were compared to determine if Tdap vaccine uptake and timing improved after the new Tdap guidelines. We additionally examined influenza and pneumococcal vaccine uptake before and after guidelines. Factors associated with receipt of the Tdap and influenza vaccine during pregnancy in the post-guideline cohort were evaluated using multivariable logistic regression models.
resultsOf 2,294 eligible individuals, 1,610 (70.2%) received care in the post-guideline cohort. Among the pre-guideline cohort, 47.4% received Tdap, whereas Tdap uptake increased to 86.1% after the guidelines (p<0.001). Similarly, receiving the Tdap vaccine between the recommended time of 27-36 weeks gestational age improved from 52.5% to 91.8% after the guidelines (p<0.001). Vaccine frequency for influenza improved significantly from 61.2% to 72.0% (p<0.001), while frequency for pneumococcus were low and unchanged. An increased number of prenatal visits was associated with receiving the Tdap and influenza vaccines during pregnancy (respective, aOR 1.09 95% CI 1.05-1.13; aOR 1.50 95% CI 1.17-1.94). Non-Hispanic Black individuals were less likely to receive both the Tdap and influenza vaccines during pregnancy compared to non-Hispanic White individuals (respective, aOR 0.51 95% CI 0.33-0.80; aOR 0.68 95% CI 0.48-0.97).
conclusionsReceipt and timing of Tdap vaccine improved after implementation of the 2012 ACIP guidelines. Receipt of influenza vaccine uptake also improved during the study period, while uptake of the pneumococcal vaccine remained low. Significant racial disparities exist in receipt of Tdap and influenza vaccine during pregnancy.
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Registered trials
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