Evidence map›Paper›PMID 34280035›Full record

ArticleInfection and immunity2021

Catalase Activity is Critical for Proteus mirabilis Biofilm Development, Extracellular Polymeric Substance Composition, and Dissemination during Catheter-Associated Urinary Tract Infection.

Ashley N White, Brian S Learman, Aimee L Brauer, Chelsie E Armbruster

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Pangenome analysis ofAntimicrobial agents and chemotherapy · 2026
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  8. Rhein againstCurrent research in food science · 2024
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  12. Into the understanding the multicellular lifestyle ofFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ashley N WhiteDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Brian S LearmanDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Aimee L BrauerDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.
Chelsie E ArmbrusterDepartment of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York, USA.ORCID 0000-0002-2165-2759
University at Buffalo, State University of New York · US

Funding

NIH R01 DK123158 Administrative SupplementR01DK123158 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ARMBRUSTER, CHELSIE ELIZABETH · 2019 to 2023
$1.8M
Pathogenesis of Polymicrobial Catheter-Associated Urinary Tract InfectionR00DK105205 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI ARMBRUSTER, CHELSIE ELIZABETH · 2018 to 2020
$727k
NIDDK NIH HHS R00 DK105205NIDDK NIH HHS R01 DK123158
6 · The paper itself

Abstract

Proteus mirabilis is a leading uropathogen of catheter-associated urinary tract infections (CAUTIs), which are among the most common health care-associated infections worldwide. A key factor that contributes to P. mirabilis pathogenesis and persistence during CAUTI is the formation of catheter biofilms, which provide increased resistance to antibiotic treatment and host defense mechanisms. Another factor that is important for bacterial persistence during CAUTI is the ability to resist reactive oxygen species (ROS), such as through the action of the catalase enzyme. Potent catalase activity is one of the defining biochemical characteristics of P. mirabilis, and the single catalase (

Indexed as

AnimalsAnti-Bacterial AgentsBacteremiaBiofilmsCatalaseCatheter-Related InfectionsCathetersCoinfectionExtracellular Polymeric Substance MatrixFemaleHumansMiceMice, Inbred CBAProteus InfectionsProteus mirabilisUrinary Tract InfectionsAnti-Bacterial AgentsCatalasebacteremiabiofilmscatalasecatheterCAUTIEPShydrogen peroxideProteus mirabilis

Identifiers

PMID34280035
PMCPMC8445196
OpenAlexW3201604573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.