Evidence map›Paper›PMID 34279947›Full record

ArticleJournal of medicinal chemistry2021

Design, Synthesis, and Characterization of Novel

Eleonora Elhalem, Ana Bellomo, Mariana Cooke, Antonella Scravaglieri, Larry V Pearce, Megan L Peach, Lucía Gandolfi Donadío, Marcelo G Kazanietz, María J Comin

Open access · greenAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Eleonora ElhalemDepartamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.
Ana BellomoDepartamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.
Mariana CookeDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Antonella ScravaglieriDepartamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.
Larry V PearceLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892-4255, United States.
Megan L PeachBasic Science Program, Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, Maryland 21702, United States.
Lucía Gandolfi DonadíoDepartamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.
Marcelo G KazanietzDepartment of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
María J CominDepartamento de Ingredientes Activos y Biorrefinerías, Instituto Nacional de Tecnología Industrial, Av. General Paz 5445, San Martín, Buenos Aires B1650WAB, Argentina.ORCID 0000-0003-2187-1932
Consejo Nacional de Investigaciones Científicas y Técnicas · AREinstein Medical Center Philadelphia · USNational Cancer Institute · USNational Institute of Industrial Technology · ARNational Institutes of Health · USTranslational Therapeutics (United States) · US

Funding

Protein kinase C and lung carcinogenesisR01ES026023 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2015 to 2019
$2.3M
Effectors of protein kinase C-mediated tumor progressionR01CA196232 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2016 to 2022
$2.0M
CXCL13: a mediator of prostate cancer progressionR01CA189765 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2015 to 2019
$1.8M
Protein kinase C and lung carcinogenesisR56ES026023 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI KAZANIETZ, MARCELO G. · 2021 to 2021
$163k
NCI NIH HHS R01 CA189765NCI NIH HHS R01 CA196232NIEHS NIH HHS R01 ES026023NIEHS NIH HHS R56 ES026023
6 · The paper itself

Abstract

DAG-lactones represent useful templates for the design of potent and selective C1 domain ligands for PKC isozymes. The ester moiety at the

Indexed as

Drug DesignDiglyceridesDose-Response Relationship, DrugHeLa CellsHeterocyclic CompoundsHumansIsoenzymesLactonesMolecular StructureProtein Kinase CStructure-Activity RelationshipDiglyceridesHeterocyclic CompoundsIsoenzymesLactonesProtein Kinase C

Identifiers

PMID34279947
PMCPMC12985396
OpenAlexW3186592205

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.