Evidence map›Paper›PMID 34279829›Full record

ArticleAdvances in experimental medicine and biology2021

Age-Specific Differences in the Severity of COVID-19 Between Children and Adults: Reality and Reasons.

Amir Tajbakhsh, Khojaste Rahimi Jaberi, Seyed Mohammad Gheibi Hayat, Mehrdad Sharifi, Thomas P Johnston, Paul C Guest, Mohammad Jafari, Amirhossein Sahebkar

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Article in Advances in experimental medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amir TajbakhshPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Khojaste Rahimi JaberiClinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Seyed Mohammad Gheibi HayatDepartment of Medical Biotechnology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Mehrdad SharifiDepartment of Emergency Medicine, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Thomas P JohnstonDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO, USA.
Paul C GuestLaboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil.
Mohammad JafariCellular and Molecular Research Center, Gerash University of Medical Sciences, Gerash, Iran. jafari@gerums.ac.ir.
Amirhossein SahebkarBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. amir_saheb2000@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, children experience mild symptoms compared to adults. However, the precise explanations for this disparity are not clear. Thus, we attempted to identify rational explanations about age-related differences as reported in different studies. Given the incomplete data on SARS-CoV-2, some information has been gathered from other studies of earlier coronavirus or influenza outbreaks. Age-related differences in disease severity are important with regard to diagnosis, prognosis, and treatment of SARS-CoV-2 infections. In addition, these differences impact social distancing needs, since pediatric patients with mild or asymptomatic are likely to play a significant role in disease transmission.

Indexed as

COVID-19Influenza, HumanAdultAge FactorsChildDisease OutbreaksHumansSARS-CoV-22019-nCoVAged adultCoronavirusCOVID-19Geriatric patientsPediatric patientsRespiratory infectionsSARS-CoV-2

Identifiers

PMID34279829

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.