Evidence map›Paper›PMID 34279757›Full record

ArticleJournal of molecular histology2021

Sox2 controls asymmetric patterning of ameloblast lineage commitment by regulation of FGF signaling in the mouse incisor.

Dan Li, Xiaofei Wang, Liping Yao, Huaixiang Jing, Tiantian Qin, Mingyue Li, Shuyu Zhang, Zhi Chen, Li Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of molecular histology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 93% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dan Li *Department of Stomatology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717 Jinbu Street, Yantai, 264100, Shandong, China.
Xiaofei Wang *Binzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Liping YaoDepartment of Cariology and Endodontology, Yantai Stomatological Hospital, Yantai, 264008, Shandong, China.
Huaixiang JingDepartment of Stomatology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717 Jinbu Street, Yantai, 264100, Shandong, China.
Tiantian QinDepartment of Stomatology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717 Jinbu Street, Yantai, 264100, Shandong, China.
Mingyue LiBinzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Shuyu ZhangBinzhou Medical University, No. 346 Guanhai Street, Yantai, 264003, Shandong, China.
Zhi ChenState Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine of Ministry of Education (KLOBM), School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, China. zhichen@whu.edu.cn.
Li ZhangDepartment of Stomatology, Yantai Affiliated Hospital of Binzhou Medical University, No. 717 Jinbu Street, Yantai, 264100, Shandong, China. zhangli@bzmc.edu.cn.ORCID http://orcid.org/0000-0002-7341-1930
Binzhou Medical University · CNWuhan University · CNYantaishan Hospital · CN

Funding

National Natural Science Foundation of China 81400479Open Research Fund Program of Hubei-MOST KLOS & KLOBM 2014-03Shandong medical and health technology development program 2018WS533
6 · The paper itself

Abstract

Mouse incisors are covered by enamel only on the labial side and the lingual side is covered by dentin without enamel. This asymmetric distribution of enamel makes it possible to be abrased on the lingual side, generating the sharp cutting edge of incisor on the labial side. The abrasion of mouse incisors is compensated by the continuous growth throughout life. Epithelium stem cells responsible for its continuous growth are reported to localize within the labial cervical loop. The transcription factor Sox2 plays important roles in the maintenance of stem cell pluripotency and organ formation. We previously found that Sox2 mainly expressed in the dental epithelium. Besides, Sox2 has been reported to be a dental epithelium stem cell marker in the incisor. However, the exact mechanism of Sox2 controlling amelogenesis is still not quite clearly elucidated. Here we report that conditional deletion of Sox2 in the dental epithelium using Shh

Indexed as

Cell LineageSignal TransductionAmeloblastsAnimalsFibroblast Growth FactorsGene DeletionGene Expression RegulationIncisorMaleMiceMice, KnockoutMouth MucosaSOXB1 Transcription FactorsFibroblast Growth FactorsSOXB1 Transcription FactorsAmeloblast lineage commitmentMouse incisorSox2Stem cell

Identifiers

PMID34279757
OpenAlexW3185281988

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.