Evidence map›Paper›PMID 34279742›Full record

ArticleFunctional & integrative genomics2021

Ancestry analysis indicates two different sets of essential genes in eukaryotic model species.

Iara D de Souza, Clovis F Reis, Diego A A Morais, Vítor G S Fernandes, João Vitor F Cavalcante, Rodrigo J S Dalmolin

Abstract read
PubMed Publisher
In one paragraph

Article in Functional & integrative genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Iara D de SouzaBioinformatics Multidisciplinary Environment - IMD, Federal University of Rio Grande Do Norte, Av. Odilon Gomes de Lima, 1722, Capim Macio, Natal, RN, 59078-400, Brazil.ORCID http://orcid.org/0000-0002-2550-6150
Clovis F ReisBioinformatics Multidisciplinary Environment - IMD, Federal University of Rio Grande Do Norte, Av. Odilon Gomes de Lima, 1722, Capim Macio, Natal, RN, 59078-400, Brazil.ORCID http://orcid.org/0000-0002-9538-9404
Diego A A MoraisBioinformatics Multidisciplinary Environment - IMD, Federal University of Rio Grande Do Norte, Av. Odilon Gomes de Lima, 1722, Capim Macio, Natal, RN, 59078-400, Brazil.ORCID http://orcid.org/0000-0002-7357-3446
Vítor G S FernandesBioinformatics Multidisciplinary Environment - IMD, Federal University of Rio Grande Do Norte, Av. Odilon Gomes de Lima, 1722, Capim Macio, Natal, RN, 59078-400, Brazil.
João Vitor F CavalcanteBioinformatics Multidisciplinary Environment - IMD, Federal University of Rio Grande Do Norte, Av. Odilon Gomes de Lima, 1722, Capim Macio, Natal, RN, 59078-400, Brazil.ORCID http://orcid.org/0000-0001-7513-7376
Rodrigo J S DalmolinBioinformatics Multidisciplinary Environment - IMD, Federal University of Rio Grande Do Norte, Av. Odilon Gomes de Lima, 1722, Capim Macio, Natal, RN, 59078-400, Brazil. rodrigo.dalmolin@imd.ufrn.br.ORCID http://orcid.org/0000-0002-1688-6155
Universidade Federal do Rio Grande do Norte · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 308258/2018-5
6 · The paper itself

Abstract

Essential genes are so-called because they are crucial for organism perpetuation. Those genes are usually related to essential functions to cellular metabolism or multicellular homeostasis. Deleterious alterations on essential genes produce a spectrum of phenotypes in multicellular organisms. The effects range from the impairment of the fertilization process, disruption of fetal development, to loss of reproductive capacity. Essential genes are described as more evolutionarily conserved than non-essential genes. However, there is no consensus about the relationship between gene essentiality and gene age. Here, we identified essential genes in five model eukaryotic species (Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster, Caenorhabditis elegans, and Mus musculus) and estimate their evolutionary ancestry and their network properties. We observed that essential genes, on average, are older than other genes in all species investigated. The relationship of network properties and gene essentiality convey with previous findings, showing essential genes as important nodes in biological networks. As expected, we also observed that essential orthologs shared by the five species evaluated here are old. However, all the species evaluated here have a specific set of young essential genes not shared among them. Additionally, these two groups of essential genes are involved with distinct biological functions, suggesting two sets of essential genes: (i) a set of old essential genes common to all the evaluated species, regulating basic cellular functions, and (ii) a set of young essential genes exclusive to each species, which perform specific essential functions in each species.

Indexed as

Caenorhabditis elegansDrosophila melanogasterEvolution, MolecularGenes, EssentialSaccharomyces cerevisiaeSchizosaccharomycesAnimalsMiceEssential genesGene evolutionGeneplastModel organismsNetwork propertiesSystems evolution

Identifiers

PMID34279742
OpenAlexW3186084157

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.