Evidence map›Paper›PMID 34279439›Full record

ReviewMolecules (Basel, Switzerland)2021

Plants and Natural Products with Activity against Various Types of Coronaviruses: A Review with Focus on SARS-CoV-2.

Susana A Llivisaca-Contreras, Jaime Naranjo-Morán, Andrea Pino-Acosta, Luc Pieters, Wim Vanden Berghe, Patricia Manzano, Jeffrey Vargas-Pérez, Fabian León-Tamariz, Juan M Cevallos-Cevallos

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 42 citations in OpenAlex.

  1. Selected Cannabinoids, Cannabimimetic Agents andPharmaceuticals (Basel, Switzerland) · 2026
    Review
  2. Review
  3. Article
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  5. Article
  6. Article
  7. Article
  8. Review
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  11. Therapeutic potential of green tea catechin, (-)-epigallocatechin-3-Phytomedicine plus : international journal of phytotherapy and phytopharmacology · 2023
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Pharmaceuticals (Basel, Switzerland) · 2022
    Article
  17. Frontiers in pharmacology · 2022
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Susana A Llivisaca-ContrerasEscuela Superior Politécnica del Litoral, ESPOL, Centro de Agua y Desarrollo Sustentable, CADS, Campus Gustavo Galindo Km. 30.5 vía Perimetral, Guayaquil EC090112, Ecuador.ORCID 0000-0001-9982-2634
Jaime Naranjo-MoránEscuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador, CIBE, Campus Gustavo Galindo Km. 30.5 vía Perimetral, Guayaquil EC090112, Ecuador.ORCID 0000-0002-4410-9337
Andrea Pino-AcostaEscuela Superior Politécnica del Litoral, ESPOL, Facultad de Arte, Diseño y Comunicación Audiovisual, FADCOM, Bosque Protector La Prosperina, Campus Gustavo Galindo Km. 30.5 vía Perimetral, Guayaquil EC090112, Ecuador.
Luc PietersNatural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0002-8288-4254
Wim Vanden BergheNatural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, 2610 Antwerp, Belgium.ORCID 0000-0003-0161-7355
Patricia ManzanoEscuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador, CIBE, Campus Gustavo Galindo Km. 30.5 vía Perimetral, Guayaquil EC090112, Ecuador.
Jeffrey Vargas-PérezEscuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador, CIBE, Campus Gustavo Galindo Km. 30.5 vía Perimetral, Guayaquil EC090112, Ecuador.
Fabian León-TamarizRed Universitaria Para la Investigación y Posgrados Vlir Network, Km. 30.5 vía Perimetral, Edificio Principal, Vicerrectorado Académico (2º Piso), Guayaquil EC090112, Ecuador.
Juan M Cevallos-CevallosEscuela Superior Politécnica del Litoral, ESPOL, Centro de Investigaciones Biotecnológicas del Ecuador, CIBE, Campus Gustavo Galindo Km. 30.5 vía Perimetral, Guayaquil EC090112, Ecuador.ORCID 0000-0003-4609-7998
Escuela Superior Politecnica del Litoral · ECUniversity of Antwerp · BEUniversity of Cuenca · EC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is a pandemic disease caused by the SARS-CoV-2 virus, which is potentially fatal for vulnerable individuals. Disease management represents a challenge for many countries, given the shortage of medicines and hospital resources. The objective of this work was to review the medicinal plants, foods and natural products showing scientific evidence for host protection against various types of coronaviruses, with a focus on SARS-CoV-2. Natural products that mitigate the symptoms caused by various coronaviruses are also presented. Particular attention was placed on natural products that stabilize the Renin-Angiotensin-Aldosterone System (RAAS), which has been associated with the entry of the SARS-CoV-2 into human cells.

Indexed as

Antiviral AgentsBiological ProductsCoronavirusCOVID-19COVID-19 Drug TreatmentHumansPandemicsPhytotherapyPlant ExtractsPlantsRenin-Angiotensin SystemSARS-CoV-2Antiviral AgentsBiological ProductsPlant Extractsangiotensin-converting enzyme inhibitors (ACEi)antiviralbiomoleculescoronavirus disease of 2019 (COVID-19)medicinal plantsmiddle east respiratory syndrome (MERS)renin–angiotensin–aldosterone system (RAAS)severe acute respiratory syndrome coronavirus (SARS-CoV)viral entry inhibitors

Identifiers

PMID34279439
PMCPMC8271932
OpenAlexW3179940071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.