Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents.
Saeb Aliwaini, Bassam Abu Thaher, Ihab Al-Masri, Nabil Shurrab, Said El-Kurdi, Dieter Schollmeyer, Basem Qeshta, Mariam Ghunaim, René Csuk, Stefan Laufer and 2 more
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
4 citing papers in PubMed, 20 citations in OpenAlex.
Said El-KurdiChemistry Department, Faculty of Science, Islamic University of Gaza, Gaza P.O. Box 108, Palestine.
Dieter SchollmeyerDepartment of Organic Chemistry, Johannes Gutenberg-University Mainz, Duesbergweg 10-14, 55099 Mainz, Germany.
Basem QeshtaChemistry Department, Faculty of Science, Islamic University of Gaza, Gaza P.O. Box 108, Palestine.
Mariam GhunaimDepartment of Biology and Biotechnology, Islamic University of Gaza, Gaza P.O. Box 108, Palestine.
René CsukDepartment of Organic Chemistry, Martin-Luther-University Halle-Wittenberg, Kurt-Mothes-Str. 2, 06120 Halle, Germany.ORCID 0000-0001-7911-290X
Stefan LauferDepartment of Pharmaceutical Chemistry, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tuebingen, Germany.ORCID 0000-0001-6952-1486
Lars KaiserInstitute of Precision Medicine, Faculty of Medical and Life Sciences, Furtwangen University (HFU), Jakob-Kienzle-Strasse 17, 78054 Villingen-Schwenningen, Germany.ORCID 0000-0002-3268-3307
Hans-Peter DeignerInstitute of Precision Medicine, Faculty of Medical and Life Sciences, Furtwangen University (HFU), Jakob-Kienzle-Strasse 17, 78054 Villingen-Schwenningen, Germany.ORCID 0000-0002-7745-0152
Islamic University of Gaza · PSAl-Azhar University – Gaza · PSFraunhofer-Gesellschaft · DEJohannes Gutenberg University Mainz · DEMartin Luther University Halle-Wittenberg · DEUniversity of Freiburg · DEUniversity of Tübingen · DE
Funding
Baden-Württemberg Ministry of Science, Research, and Culture funding program Open Access PublishingCooperation Council for the Arab States of the Gulf through the Islamic Development Bank Ibhath project
6 · The paper itself
Abstract
Three novel pyrazolo-[4,3-
Indexed as
Antineoplastic AgentsBinding SitesCell ProliferationErbB ReceptorsHeLa CellsHumansMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Molecular Docking SimulationProtein BindingProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPyrimidinesTriazolesAKT1 protein, humanAntineoplastic AgentsErbB ReceptorsMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Protein Kinase InhibitorsProto-Oncogene Proteins c-aktPyrimidinesTriazolesbreast cancercervical cancercrystal X-ray analysisEGF-receptor inhibitormolecular dockingpyrazolo[1,2,4]triazolopyrimidine
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Design, Synthesis and Biological Evaluation of Novel Pyrazolo[1,2,4]triazolopyrimidine Derivatives as Potential Anticancer Agents. · full record | OpenQuestion