Evidence map›Paper›PMID 34279377›Full record

ArticleMolecules (Basel, Switzerland)2021

The Effect of the Molecular Weight of Polyvinylpyrrolidone and the Model Drug on Laser-Induced In Situ Amorphization.

Nele-Johanna Hempel, Padryk Merkl, Matthias Manne Knopp, Ragna Berthelsen, Alexandra Teleki, Anders Kragh Hansen, Georgios A Sotiriou, Korbinian Löbmann

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nele-Johanna HempelDepartment of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-1021-6898
Padryk MerklDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177 Stockholm, Sweden.ORCID 0000-0002-8922-3774
Matthias Manne KnoppBioneer:FARMA, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.
Ragna BerthelsenDepartment of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-5992-9688
Alexandra TelekiScience for Life Laboratory, Department of Pharmacy, Uppsala University, 75123 Uppsala, Sweden.ORCID 0000-0001-6514-8960
Anders Kragh HansenDepartment of Photonics Engineering, Technical University of Denmark, 4000 Roskilde, Denmark.ORCID 0000-0002-4632-6538
Georgios A SotiriouDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institute, 17177 Stockholm, Sweden.ORCID 0000-0001-5040-620X
Korbinian LöbmannDepartment of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.ORCID 0000-0002-8710-6347
University of Copenhagen · DKKarolinska Institutet · SETechnical University of Denmark · DKUppsala University · SE

Funding

Danmarks Frie Forskningsfond DFF-7026-00052BEuropean Research Council 758705NordForsk 85352Stiftelsen för Strategisk Forskning FFL18-0043Vetenskapsrådet 2016-03471
6 · The paper itself

Abstract

Laser radiation has been shown to be a promising approach for in situ amorphization, i.e., drug amorphization inside the final dosage form. Upon exposure to laser radiation, elevated temperatures in the compacts are obtained. At temperatures above the glass transition temperature (

Indexed as

Infrared RaysAnti-Inflammatory Agents, Non-SteroidalCelecoxibDrug StabilityLasersNanoparticlesPovidoneViscosityAnti-Inflammatory Agents, Non-SteroidalCelecoxibPovidoneamorphous solid dispersiondissolution kineticsin situ amorphizationnear-IR laser radiationplasmonic photothermal nanoparticles

Identifiers

PMID34279377
PMCPMC8271673
OpenAlexW3173947197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.