Evidence map›Paper›PMID 34279375›Full record

ArticleMolecules (Basel, Switzerland)2021

Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing.

Xushan Chen, Huimin Zhang, Xin Yang, Wuhong Zhang, Ming Jiang, Ting Wen, Jie Wang, Rui Guo, Hanjiao Liu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Antibiotic Nanoparticles-Loaded Wound Dressings AgainstInternational journal of nanomedicine · 2024
    Pooled it
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  19. Hydrogels in Burn Wound Management-A Review.Gels (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xushan ChenShenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China.
Huimin ZhangShenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China.
Xin YangShenzhen Bao'an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518033, China.
Wuhong ZhangShenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China.
Ming JiangKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
Ting WenFujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Jie WangFujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Rui GuoKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-7674-073X
Hanjiao LiuShenzhen Bao'an Traditional Chinese Medicine Hospital Group, Shenzhen 518133, China.
Fujian University of Traditional Chinese Medicine · CNJinan University · CNGuangzhou University of Chinese Medicine · CN

Funding

Medical research foundation of Guangdong province A2019228National Natural Science Foundation of China 81972080Natural Science Foundation of Guangdong Province 2015A030312004Research Program of PLA 20QNPY083, CGZ16C004Science and Technology Planning Project of Guangdong Province 2017B030314139Science and Technology Planning Project of Guangzhou 202002030304
6 · The paper itself

Abstract

Infection is the major reason that people die from burns; however, traditional medical dressings such as gauze cannot restrain bacterial growth and enhance the healing process. Herein, an organic- and inorganic-base hydrogel with antibacterial activities was designed and prepared to treat burn wounds. Oxidized dextran (ODex) and adipic dihydrazide grafted hyaluronic acid (HA-ADH) were prepared, mixed with quaternized chitosan (HACC) and silver nanoparticles to fabricate Ag@ODex/HA-ADH/HACC hydrogel. The hydrogel, composed of nature biomaterials, has a good cytocompatibility and biodegradability. Moreover, the hydrogel has an excellent antibacterial ability and presents fast healing for burn wounds compared with commercial Ag dressings. The Ag@ODex/HA-ADH/HACC hydrogel will be a promising wound dressing to repair burn wounds and will significantly decrease the possibility of bacterial infection.

Indexed as

Wound HealingAdipatesAnimalsAnti-Bacterial AgentsBandagesBurnsCell LineChitosanDextransHydrogelsMaleMetal NanoparticlesMicePseudomonas aeruginosaRatsRats, Sprague-DawleyAdipatesadipic dihydrazideAnti-Bacterial AgentsChitosanDextransHydrogelsSilverantibacterial hydrogelinfected burn woundsilver nanoparticles

Identifiers

PMID34279375
PMCPMC8271850
OpenAlexW3177349429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.