Evidence map›Paper›PMID 34279352›Full record

ArticlePolymers2021

Mannose-Modified Chitosan Poly(lactic-

Haibo Feng, Xiaonong Yang, Linzi Zhang, Qianqian Liu, Yangyang Feng, Daiyan Wu, Yunjie Liu, Jie Yang

Open access · goldAbstract read
In one paragraph

Article in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Pharmaceutics · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haibo FengCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.ORCID 0000-0003-1106-7588
Xiaonong YangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.
Linzi ZhangCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.
Qianqian LiuCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.
Yangyang FengCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.
Daiyan WuCollege of Animal Husbandry and Veterinary Medicine, Southwest Minzu University, Chengdu 610041, China.
Yunjie LiuDepartment of Veterinary Medicine, Southwest University, Rongchang 402460, China.
Jie YangDepartment of Veterinary Medicine, Southwest University, Rongchang 402460, China.
Southwest Minzu University · CNSouthwest University · CN

Funding

Applied Basic Research Program of Sichuan Province 2021YJ0289Fundamental Research Funds for the Central Universities 2020NYB22National Natural Science Foundation of China 31872511
6 · The paper itself

Abstract

The mannose receptor (MAN-R)-targeted delivery system is commonly used to deliver antigens to macrophages or immature dendritic cells (DCs) to promote the efficiency of antigen presentation. To maximize the enhancement effects of chitosan (CS) and induce an efficient humoral and cellular immune response against an antigen, we encapsulated ovalbumin (OVA) in poly(lactic-co-glycolic acid) (PLGA) microspheres (MPs) and conjugated it with MAN-modified CS to obtain MAN-R-targeting nano-MPs (MAN-CS-OVA-PLGA-MPs). The physicochemical properties, drug loading rate, and immunomodulation activity of MAN-CS-OVA-PLGA-MPs were evaluated. In vitro, MAN-CS-OVA-PLGA-MPs (80 μg mL

Indexed as

delivery systemdendritic cellsmannose-modified chitosanmannose receptorPLGA nanomicrospheres

Identifiers

PMID34279352
PMCPMC8271610
OpenAlexW3181051595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.