Evidence map›Paper›PMID 34279306›Full record

ArticleMaterials (Basel, Switzerland)2021

Titanium Functionalized with Polylysine Homopolymers: In Vitro Enhancement of Cells Growth.

Maria Contaldo, Alfredo De Rosa, Ludovica Nucci, Andrea Ballini, Davide Malacrinò, Marcella La Noce, Francesco Inchingolo, Edit Xhajanka, Kenan Ferati, Arberesha Bexheti-Ferati and 2 more

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Design of Materials for Bone Tissue Scaffolds.Materials (Basel, Switzerland) · 2021
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Maria ContaldoMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.ORCID 0000-0002-4773-6694
Alfredo De RosaMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.ORCID 0000-0002-5044-4318
Ludovica NucciMultidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Via Luigi de Crecchio, 6, 80138 Naples, Italy.ORCID 0000-0002-7174-7596
Andrea BalliniDepartment of Biosciences, Biotechnologies and Biopharmaceutics, Campus Universitario Ernesto Quagliariello, University of Bari "Aldo Moro", 70125 Bari, Italy.ORCID 0000-0001-8758-1415
Davide MalacrinòDepartment of Research, Development and Quality Assessment, AISER SA, Rue du Rhone, 14 VH-1204 Genève, Switzerland.
Marcella La NoceDepartment of Experimental Medicine, Università Degli Studi della Campania Luigi Vanvitelli, Campania, 80138 Naples, Italy.ORCID 0000-0002-8782-3821
Francesco InchingoloDepartment of Interdisciplinary Medicine, University of Medicine Aldo Moro, 70124 Bari, Italy.ORCID 0000-0003-3797-5883
Edit XhajankaDepartment of Dental Prosthesis, Medical University of Tirana, Rruga e Dibrës, U.M.T., 1001 Tirana, Albania.ORCID 0000-0002-0843-5231
Kenan FeratiFaculty of Medicine, University of Tetovo, 1220 Tetovo, North Macedonia.
Arberesha Bexheti-FeratiFaculty of Medicine, University of Tetovo, 1220 Tetovo, North Macedonia.
Antonia FeolaDepartment of Biology, University of Naples "Federico II", 80138 Naples, Italy.
Marina Di DomenicoDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
University of Campania "Luigi Vanvitelli" · ITState University of Tetova · MKUniversity of Bari Aldo Moro · ITUniversity of Naples Federico II · ITUniversity of Tirana · AL

Funding

SANIDENT S.R.L. Via Settembrini, Milan, Italy, with the Department of Precision Medicine, University of Campania "Luigi Vanvitel-li", Naples, Italy. 29/01/2020
6 · The paper itself

Abstract

In oral implantology, the success and persistence of dental implants over time are guaranteed by the bone formation around the implant fixture and by the integrity of the peri-implant mucosa seal, which adheres to the abutment and becomes a barrier that hinders bacterial penetration and colonization close to the outer parts of the implant. Research is constantly engaged in looking for substances to coat the titanium surface that guarantees the formation and persistence of the peri-implant bone, as well as the integrity of the mucous perimeter surrounding the implant crown. The present study aimed to evaluate in vitro the effects of a titanium surface coated with polylysine homopolymers on the cell growth of dental pulp stem cells and keratinocytes to establish the potential clinical application. The results reported an increase in cell growth for both cellular types cultured with polylysine-coated titanium compared to cultures without titanium and those without coating. These preliminary data suggest the usefulness of polylysine coating not only for enhancing osteoinduction but also to speed the post-surgery mucosal healings, guarantee appropriate peri-implant epithelial seals, and protect the fixture against bacterial penetration, which is responsible for compromising the implant survival.

Indexed as

biomaterialscell growthdental implantsepithelial growthimplantologypolylysinetitanium

Identifiers

PMID34279306
PMCPMC8269806
OpenAlexW3179409024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.