ArticleMaterials (Basel, Switzerland)2021
Temporal Imaging of Live Cells by High-Speed Confocal Raman Microscopy.
Article in Materials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Label-free correlative morpho-chemical tomography of 3D kidney mesangial cells.Journal of biomedical optics · 2026Article
- Identification of the Cellular Tipping Point in the Inflammation Model of LPS-Induced RAW264.7 Macrophages Through Raman Spectroscopy and the Dynamical Network Biomarker Theory.Molecules (Basel, Switzerland) · 2025Article
- Prediction of single-cell RNA expression profiles in live cells by Raman microscopy with Raman2RNA.Nature biotechnology · 2024Article
- Label-free morpho-molecular phenotyping of living cancer cells by combined Raman spectroscopy and phase tomography.Communications biology · 2024Article
- Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells.Biosensors · 2023Article
- Recent Advances in Enhancement of Raman Scattering Intensity for Biological Applications.Chemical & biomedical imaging · 2023Review
- Analytical Techniques for Single-Cell Biochemical Assays of Lipids.Annual review of biomedical engineering · 2023Review
- Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy.PeerJ · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Label-free live cell imaging was performed using a custom-built high-speed confocal Raman microscopy system. For various cell types, cell-intrinsic Raman bands were monitored. The high-resolution temporal Raman images clearly delineated the intracellular distribution of biologically important molecules such as protein, lipid, and DNA. Furthermore, optical phase delay measured using quantitative phase microscopy shows similarity with the image reconstructed from the protein Raman peak. This reported work demonstrates that Raman imaging is a powerful label-free technique for studying various biomedical problems in vitro with minimal sample preparation and external perturbation to the cellular system.
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Registered trials
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