Evidence map›Paper›PMID 34279214›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2021

Improving outcomes of hypoglossal nerve stimulation therapy: current practice, future directions, and research gaps. Proceedings of the 2019 International Sleep Surgery Society Research Forum.

Maria V Suurna, Ofer Jacobowitz, Jolie Chang, Ioannis Koutsourelakis, David Smith, Uri Alkan, Mark D'Agostino, Maurits Boon, Clemens Heiser, Paul Hoff and 13 more

Abstract read
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Comparison of clinical pathways for hypoglossal nerve stimulation management: in-laboratory titration polysomnography vs home-based efficacy sleep testing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
    Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Adherence to unilateral hypoglossal nerve stimulation and changes in Epworth Sleepiness Scale scores.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  7. The benefits of capturing patient-reported outcome measures for treatment of obstructive sleep apnea with hypoglossal nerve stimulation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  8. Article
  9. The impact of neck circumference on hypoglossal nerve stimulator therapy outcomes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Article
  10. Article
  11. Use of Hypoglossal Nerve Stimulation for Treating OSA in Military Patient Populations.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2024
    Review
  12. Article
  13. Article
  14. Treatment options in obstructive sleep apnea.Internal and emergency medicine · 2022
    Review
  15. The hidden magic of hypoglossal nerve stimulation therapy: organizing the sleep surgery research community.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Maria V SuurnaDivision of Sleep Surgery, Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medicine/New York Presbyterian Hospital, New York, New York.
Ofer JacobowitzENT and Allergy Associates, New York, New York.
Jolie ChangDivision of Sleep Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California.
Ioannis KoutsourelakisMideterraneo Hospital, Athens, Greece.
David SmithDivisions of Pediatric Otolaryngology, Pulmonary Medicine, and the Sleep Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Uri AlkanDepartment of Otorhinolaryngology, Head and Neck Surgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Mark D'AgostinoSouthern New England Ear, Nose, Throat and Facial Plastic Surgery Group and Middlesex Hospital, Middletown, Connecticut.
Maurits BoonOtolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
Clemens HeiserDepartment of Otorhinolaryngology, Head and Neck Surgery, Technische Universität München, Munich, Germany.
Paul HoffDepartment of Otolaryngology, University of Michigan, Ann Arbor, Michigan.
Colin HuntleyOtolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania.
David KentDepartment of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tennessee.
Alan KominskyHead and Neck Institute, Cleveland Clinic, Cleveland, Ohio.
Richard LewisPerth Head and Neck Surgery, Hollywood Medical Centre, Nedlands, Australia.
Joachim T MaurerDivision of Sleep Medicine, Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Madeline J RaveslootDepartment of Ear, Nose and Throat, OLVG, Amsterdam, Netherlands.
Ryan SooseDivision of Sleep Surgery, Department of Otolaryngology, Pittsburgh School of Medicine, UPMC Mercy, University of Pittsburgh, Pittsburgh, Pennsylvania.
Armin SteffenDepartment of Otorhinolaryngology, University of Lübeck, Lübeck, Germany.
Edward M WeaverDepartment of Otolaryngology-Head and Neck Surgery, University of Washington, Surgery Service, Seattle Veterans Affairs Medical Center; Harborview Medical Center, Seattle, Washington.
Amy M WilliamsDepartment of Otolaryngology-Head and Neck Surgery of Henry Ford Health System, Detroit, Michigan.
Tucker WoodsonDivision of Sleep Medicine and Sleep Surgery, Department of Otolaryngology and Human Communication of Medical College of Wisconsin, Milwaukee, Wisconsin.
Kathleen YaremchukDepartment of Otolaryngology-Head and Neck Surgery of Henry Ford Health System, Detroit, Michigan.
Stacey L IshmanDivisions of Pediatric Otolaryngology, Pulmonary Medicine, and the Sleep Center, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Funding

Circadian Clock Dysregulation in a Model of Obstructive Sleep ApneaK08HL148551 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI SMITH, DAVID F · 2019 to 2023
$818k
NHLBI NIH HHS K08 HL148551
6 · The paper itself

Abstract

Hypoglossal nerve stimulation (HGNS) has evolved as a novel and effective therapy for patients with moderate-to-severe obstructive sleep apnea. Despite positive published outcomes of HGNS, there exist uncertainties regarding proper patient selection, surgical technique, and the reporting of outcomes and individual factors that impact therapy effectiveness. According to current guidelines, this therapy is indicated for select patients, and recommendations are based on the Stimulation Therapy for Apnea Reduction or STAR trial. Ongoing research and physician experiences continuously improve methods to optimize the therapy. An understanding of the way in which airway anatomy, obstructive sleep apnea phenotypes, individual health status, psychological conditions, and comorbid sleep disorders influence the effectiveness of HGNS is essential to improve outcomes and expand therapy indications. This article presents discussions on current evidence, future directions, and research gaps for HGNS therapy from the 10th International Surgical Sleep Society expert research panel. CITATION: Suurna MV, Jacobowitz O, Chang J, et al. Improving outcomes of hypoglossal nerve stimulation therapy: current practice, future directions and research gaps. Proceedings of the 2019 International Sleep Surgery Society Research Forum.

Indexed as

Electric Stimulation TherapySleep Apnea, ObstructiveHumansHypoglossal NervePolysomnographySleephypoglossal nerve stimulationneurostimulationOSAOSA treatmentsleep apneasleep surgery outcomesupper airway stimulationupper airway surgery

Identifiers

PMID34279214
PMCPMC8726368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.