Evidence map›Paper›PMID 34278745›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2021

Biodegradable and Dual-Responsive Polypeptide-Shelled Cyclodextrin-Containers for Intracellular Delivery of Membrane-Impermeable Cargo.

Sergej Kudruk, Sharafudheen Pottanam Chali, Anna Livia Linard Matos, Cole Bourque, Clara Dunker, Christos Gatsogiannis, Bart Jan Ravoo, Volker Gerke

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sergej KudrukInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Von-Esmarch-Str. 56, Münster, 48149, Germany.
Sharafudheen Pottanam ChaliCenter for Soft Nanoscience and Organic Chemistry Institute, University of Muenster, Busso Peus Straße 10, Münster, 48149, Germany.
Anna Livia Linard MatosInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Von-Esmarch-Str. 56, Münster, 48149, Germany.
Cole BourqueCenter for Soft Nanoscience and Institute of Medical Physics and Biophysics, University of Muenster, Busso Peus Straße 10, Münster, 48149, Germany.
Clara DunkerInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Von-Esmarch-Str. 56, Münster, 48149, Germany.
Christos GatsogiannisCenter for Soft Nanoscience and Institute of Medical Physics and Biophysics, University of Muenster, Busso Peus Straße 10, Münster, 48149, Germany.
Bart Jan RavooCenter for Soft Nanoscience and Organic Chemistry Institute, University of Muenster, Busso Peus Straße 10, Münster, 48149, Germany.ORCID 0000-0003-2202-7485
Volker GerkeInstitute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Von-Esmarch-Str. 56, Münster, 48149, Germany.ORCID 0000-0001-7208-8206

Funding

Deutsche Forschungsgemeinschaft GE514/6-3Deutsche Forschungsgemeinschaft SFB 858/B19
6 · The paper itself

Abstract

The transport of membrane impermeable compounds into cells is a prerequisite for the efficient cellular delivery of hydrophilic and amphiphilic compounds and drugs. Transport into the cell's cytosolic compartment should ideally be controllable and it should involve biologically compatible and degradable vehicles. Addressing these challenges, nanocontainers based on cyclodextrin amphiphiles that are stabilized by a biodegradable peptide shell are developed and their potential to deliver fluorescently labeled cargo into human cells is analyzed. Host-guest mediated self-assembly of a thiol-containing short peptide or a cystamine-cross-linked polypeptide shell on cyclodextrin vesicles produce short peptide-shelled (SPSV

Indexed as

Drug LiberationHydrophobic and Hydrophilic InteractionsCyclodextrinsDrug Delivery SystemsEndothelial CellsHumansNanoparticlesPeptidesCyclodextrinsPeptidesbiodegradablecyclodextrindual-responsiveintracellular deliverypolypeptides

Identifiers

PMID34278745
PMCPMC8456233

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.