ArticleNeuromodulation : journal of the International Neuromodulation Society2023
Mechanisms Underlying Poststimulation Block Induced by High-Frequency Biphasic Stimulation.
Article in Neuromodulation : journal of the International Neuromodulation Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 10 citations in OpenAlex.
- Closed-loop electrical block of vagus nerve scales from rodent to porcine cardiac models.Journal of neural engineering · 2025Article
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Response of dorsal horn neurons in mice to high-frequency (kHz) biphasic stimulation is not sensitive to local temperature rise.Physiological reports · 2025Article
- Pudendal Nerve Block by Adaptively Stepwise Increasing the Intensity of High-Frequency (10 kHz) Biphasic Stimulation.Neuromodulation : journal of the International Neuromodulation Society · 2025Article
- Model Analysis of Post-Stimulation Block of a Myelinated Axon by Direct Current.IEEE transactions on bio-medical engineering · 2023Article
- High frequency alternating current neurostimulation decreases nocifensive behavior in a disc herniation model of lumbar radiculopathy.Bioelectronic medicine · 2023Article
- Intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency biphasic stimulation.Journal of neural engineering · 2022Article
- High-frequency stimulation induces axonal conduction block without generating initial action potentials.Journal of computational neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveTo reveal the possible mechanisms underlying poststimulation block induced by high-frequency biphasic stimulation (HFBS). MATERIALS AND
methodsA new axonal conduction model is developed for unmyelinated axons. This new model is different from the classical axonal conduction model by including both ion concentrations and membrane ion pumps to allow analysis of axonal responses to long-duration stimulation. Using the new model, the post-HFBS block phenomenon reported in animal studies is simulated and analyzed for a wide range of stimulation frequencies (100 Hz-10 kHz).
resultsHFBS can significantly change the Na
conclusionThis study reveals two possible ionic mechanisms underlying post-HFBS block of axonal conduction. Understanding these mechanisms is important for improving clinical applications of HFBS block and for developing new nerve block methods employing HFBS.
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Registered trials
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