ArticleAddiction biology2022
Adolescent social isolation induced alterations in nucleus accumbens glutamate signalling.
Article in Addiction biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Adolescent social isolation promotes oxycodone consumption and augments mu opioid receptor responsiveness in the ventral pallidum.Addiction neuroscience · 2026Article
- Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Article
- Sex differences in AMPA receptor trafficking proteins.Biology of sex differences · 2026Review
- Effects of acute adolescent stress on the acquisition and maintenance of intravenous oxycodone self-administration in male and female rats.Drug and alcohol dependence · 2026Article
- Adolescent social isolation associated changes in ethanol-induced dopamine regulation in the ventral pallidum.Addiction neuroscience · 2025Article
- Effects of acute adolescent stress on the acquisition and maintenance of intravenous oxycodone self-administration in male and female rats.bioRxiv : the preprint server for biology · 2025Article
- Frequency-Dependent Modulation of Short-Term Neuronal Dynamics in the Female and Male Dorsal and Ventral Rat Hippocampus.International journal of molecular sciences · 2025Article
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- The effects of different types of social interactions on the electrophysiology of neurons in the nucleus accumbens in rodents.Neuroscience and biobehavioral reviews · 2024Review
- Social isolation postweaning alters reward-related dopamine dynamics in a region-specific manner in adolescent male rats.Neurobiology of stress · 2024Article
- Synaptic pruning during adolescence shapes adult social behavior in both males and females.Developmental psychobiology · 2024Article
- Sex differences in glutamate transmission and plasticity in reward related regions.Frontiers in behavioral neuroscience · 2024Review
- Post-weaning social isolation alters sociability in a sex-specific manner.Frontiers in behavioral neuroscience · 2024Article
- Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core.Biology of sex differences · 2023Article
- Article
- Post-weaning social isolation causes sex-specific alterations to dendritic spine density in subregions of the prefrontal cortex and nucleus accumbens of adult mice.Brain research · 2022Article
- A molecular framework for autistic experiences: Mitochondrial allostatic load as a mediator between autism and psychopathology.Frontiers in psychiatry · 2022Article
- Long-Term Impacts of Post-weaning Social Isolation on Nucleus Accumbens Function.Frontiers in psychiatry · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Exposure to adversity during early childhood and adolescence increases an individual's vulnerability to developing substance use disorder. Despite the knowledge of this vulnerability, the mechanisms underlying it are still poorly understood. Excitatory afferents to the nucleus accumbens (NAc) mediate responses to both stressful and rewarding stimuli. Understanding how adolescent social isolation alters these afferents could inform the development of targeted interventions both before and after drug use. Here, we used social isolation rearing as a model of early life adversity which we have previously demonstrated increases vulnerability to cocaine addiction-like behaviour. The current study examined the effect of social isolation rearing on presynaptic glutamatergic transmission in NAc medium spiny neurons in both male and female mice. We show that social isolation rearing alters presynaptic plasticity in the NAc by decreasing the paired-pulse ratio and the size of the readily releasable pool of glutamate. Optogenetically activating the glutamatergic input from the ventral hippocampus to the NAc is sufficient to recapitulate the decreases in paired-pulse ratio and readily releasable pool size seen following electrical stimulation of all NAc afferents. Further, optogenetically inhibiting the ventral hippocampal afferent during electrical stimulation eliminates the effect of early life adversity on the paired-pulse ratio or readily releasable pool size. In summary, we demonstrate that social isolation rearing leads to alterations in glutamate transmission driven by projections from the ventral hippocampus. These data suggest that targeting the circuit from the ventral hippocampus to the nucleus accumbens could provide a means to reverse stress-induced plasticity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.