Evidence map›Paper›PMID 34278466›Full record

ArticleMolecular medicine reports2021

Chemokine CCL20 promotes the paclitaxel resistance of CD44

Min Chen, Juan Su, Chunmei Feng, Ying Liu, Li Zhao, Yongjie Tian

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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  5. Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Min ChenDepartment of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.
Juan SuDepartment of Obstetrics and Gynecology, Taian City Central Hospital, Taian, Shandong 271000, P.R. China.
Chunmei FengDepartment of Obstetrics and Gynecology, Taian City Central Hospital, Taian, Shandong 271000, P.R. China.
Ying LiuDepartment of Obstetrics and Gynecology, Taian City Central Hospital, Taian, Shandong 271000, P.R. China.
Li ZhaoDepartment of Obstetrics and Gynecology, Taian City Central Hospital, Taian, Shandong 271000, P.R. China.
Yongjie TianDepartment of Obstetrics and Gynecology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.
Taian City Central Hospital · CNShandong Provincial Hospital · CNShandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have found that C‑C motif chemokine ligand 20 (CCL20)/C‑C motif chemokine receptor 6 (CCR6)/notch receptor 1 (Notch1) signaling serves an important role in various diseases, but its role and mechanism in ovarian cancer remains to be elucidated. The aim of the present study was to investigate the underlying mechanism of CCL20/CCR6/Notch1 signaling in paclitaxel (PTX) resistance of a CD44

Indexed as

AnimalsApoptosisCell Line, TumorChemokine CCL20Drug Resistance, NeoplasmFemaleHumansHyaluronan ReceptorsLigandsMiceMice, NudeOvarian NeoplasmsPaclitaxelProto-Oncogene Proteins c-kitReceptor, Notch1Receptors, ChemokineCCL20 protein, mouseCd44 protein, mouseChemokine CCL20Hyaluronan ReceptorsLigandsNotch1 protein, mousePaclitaxelProto-Oncogene Proteins c-kitReceptor, Notch1Receptors, ChemokineC‑C motif chemokine ligand 20/C‑C motif chemokine receptor 6 axisnotch receptor 1 pathwayovarian cancer stem‑like cellspaclitaxel resistance

Identifiers

PMID34278466
PMCPMC8280726
OpenAlexW3180178824

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.