Evidence map›Paper›PMID 34278398›Full record

ArticleDalton transactions (Cambridge, England : 2003)2021

Platinum(IV)-azido monocarboxylato complexes are photocytotoxic under irradiation with visible light.

Evyenia Shaili, Marίa J Romero, Luca Salassa, Julie A Woods, Jennifer S Butler, Isolda Romero-Canelón, Guy Clarkson, Abraha Habtemariam, Peter J Sadler, Nicola J Farrer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Evyenia ShailiDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk.
Marίa J RomeroDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk and Departamento de Didácticas Aplicadas, Facultade de Formación do Profesorado, Universidade de Santiago de Compostela, 27002, Lugo, Spain.
Luca SalassaDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk and Donostia International Physics Center, Paseo Manuel de Lardizabal 4, Donostia, 20018, Spain and Polimero eta Material Aurreratuak: Fisika, Kimika eta Teknologia, Kimika Fakultatea, Euskal Herriko Unibertsitatea UPV/EHU, Paseo Manuel de Lardizabal 3, Donostia, 20018, Spain and Ikerbasque, Basque Foundation for Science, Bilbao, 48011, Spain.ORCID http://orcid.org/0000-0002-2112-9095
Julie A WoodsPhotobiology Unit, Department of Dermatology and Photobiology, Ninewells Hospital, Dundee, DD1 9SY, UK.
Jennifer S ButlerDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk.
Isolda Romero-CanelónDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk and School of Pharmacy, Institute of Clinical Sciences, College of Medical and Dental Sciences, Sir Robert Aitken Institute for Medical Research, University of Birmingham, Birmingham, B15 2TT, UK.ORCID http://orcid.org/0000-0003-3847-4626
Guy ClarksonDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk.ORCID http://orcid.org/0000-0003-3076-3191
Abraha HabtemariamDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk.
Peter J SadlerDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk.ORCID http://orcid.org/0000-0001-9160-1941
Nicola J FarrerDepartment of Chemistry, University of Warwick, Gibbet Hill Road, Coventry, CV4 7AL, UK. p.j.sadler@warwick.ac.uk and Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK. Nicola.Farrer@chem.ox.ac.uk.ORCID http://orcid.org/0000-0002-7440-1291

Funding

Wellcome Trust 201406/Z/16/Z
6 · The paper itself

Abstract

Complexes trans,trans,trans-[Pt(N3)2(OH)(OCOR)(py)2] where py = pyridine and where OCOR = succinate (1); 4-oxo-4-propoxybutanoate (2) and N-methylisatoate (3) have been synthesized by derivation of trans,trans,trans-[Pt(OH)2(N3)2(py)2] (4) and characterised by NMR and EPR spectroscopy, ESI-MS and X-ray crystallography. Irradiation of 1-3 with green (517 nm) light initiated photoreduction to Pt(ii) and release of the axial ligands at a 3-fold faster rate than for 4. TD-DFT calculations showed dissociative transitions at longer wavelengths for 1 compared to 4. Complexes 1 and 2 showed greater photocytotoxicity than 4 when irradiated with 420 nm light (A2780 cell line IC50 values: 2.7 and 3.7 μM) and complex 2 was particularly active towards the cisplatin-resistant cell line A2780cis (IC50 3.7 μM). Unlike 4, complexes 1-3 were phototoxic under green light irradiation (517 nm), with minimal toxicity in the dark. A pKa(H2O) of 5.13 for the free carboxylate group was determined for 1, corresponding to an overall negative charge during biological experiments, which crucially, did not appear to impede cellular accumulation and photocytotoxicity.

Indexed as

Antineoplastic AgentsLightCell Line, TumorCell SurvivalCoordination ComplexesDensity Functional TheoryDrug Screening Assays, AntitumorHumansModels, MolecularMolecular StructureOrganoplatinum CompoundsPhotochemical ProcessesPhotosensitizing AgentsPlatinumAntineoplastic AgentsCoordination ComplexesOrganoplatinum CompoundsPhotosensitizing AgentsPlatinum

Identifiers

PMID34278398
PMCPMC8335519

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.