Evidence map›Paper›PMID 34278362›Full record

ArticleF&S reports2021

Oocyte cryopreservation in a transgender man on long-term testosterone therapy: a case report.

Jenna Gale, Bryden Magee, Amanda Forsyth-Greig, Hasina Visram, Aaron Jackson

Open access · goldAbstract read
In one paragraph

Article in F&S reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Pooled it
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  13. Reproductive capacity after gender-affirming testosterone therapy.Human reproduction (Oxford, England) · 2023
    Article
  14. Article
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  20. Fertility counseling guide for transgender and gender diverse people.International journal of transgender health · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Jenna GaleDepartment of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada.
Bryden MageeDepartment of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada.
Amanda Forsyth-GreigDepartment of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada.
Hasina VisramDepartment of Obstetrics and Gynecology, Queens University, Kingston, Ontario, Canada.
Aaron JacksonDepartment of Obstetrics and Gynecology, University of Ottawa, Ottawa, Ontario, Canada.
Ottawa Fertility Centre · CAUniversity of Ottawa · CAQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo report a case of ovarian stimulation for the purposes of oocyte cryopreservation in a transgender man without cessation of long-term testosterone therapy.

designReport of a unique case of fertility preservation through ovarian stimulation and oocyte cryopreservation in a transgender man who had been on testosterone therapy for 18 months before treatment. The patient elected to continue testosterone therapy throughout ovarian stimulation and oocyte retrieval. To our knowledge, there have not been any published reports of patients undergoing oocyte cryopreservation while continuing long-term testosterone therapy.

settingPrivate fertility clinic with university affiliation. PATIENTS: A 20-year-old transgender man undergoing oocyte cryopreservation before gonadectomy.

interventionsFertility preservation through oocyte cryopreservation.

main outcome measuresThis patient had a robust response to ovarian gonadotropin stimulation. Leuprolide acetate was used for final oocyte maturation to minimize ovarian hyperstimulation syndrome risk.

resultsCryopreservation of 22 mature oocytes.

conclusionsCryopreservation of mature oocytes is possible for patients on continued long-term testosterone therapy. The impact of long-term testosterone therapy on markers of ovarian reserve, reproductive potential, and long-term reproductive outcomes have yet to be elucidated and further studies are needed in this area.

Indexed as

fertility preservationOocyte cryopreservationovarian stimulationtestosteronetransgender men

Identifiers

PMID34278362
PMCPMC8267393
OpenAlexW3131075118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.