Evidence map›Paper›PMID 34278336›Full record

ArticleSTAR protocols2021

Transcriptional analysis of mouse wounds grafted with human mesenchymal stem cells and platelets.

Jennyfer Levoux, Peggy Lafuste, Anne-Marie Rodriguez

Abstract read
In one paragraph

Article in STAR protocols, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jennyfer LevouxUniv Paris Est Creteil, INSERM, IMRB, 94010 Créteil, France.
Peggy LafusteUniv Paris Est Creteil, INSERM, IMRB, 94010 Créteil, France.
Anne-Marie RodriguezUniv Paris Est Creteil, INSERM, IMRB, 94010 Créteil, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet preparations are commonly used in the clinic in combination with mesenchymal stem cells (MSCs) to improve their wound healing capacity and optimize their therapeutic efficacy following their delivery into diseased tissues. To investigate the mechanisms by which platelets enhance the repair properties of MSCs, we detail a protocol using a humanized mouse model for excisional wounds to study by reverse transcription real-time PCR whether human platelets alter the therapeutic efficacy of grafted human MSCs. For complete details on the use and execution of this protocol, please refer to Levoux et al. (2021).

Indexed as

AnimalsBlood PlateletsGene Expression ProfilingHeterograftsHumansMaleMesenchymal Stem Cell TransplantationMiceMice, Inbred C57BLPlatelet TransfusionReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionWounds, PenetratingCell BiologyHealth SciencesMetabolismModel OrganismsMolecular BiologyStem Cells

Identifiers

PMID34278336
PMCPMC8261014

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.