ArticleAdversity and resilience science2020
Is There an Ace Up Our Sleeve? A Review of Interventions and Strategies for Addressing Behavioral and Neurobiological Effects of Adverse Childhood Experiences in Youth.
Article in Adversity and resilience science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07118072 (Internet-Delivered Skills Training in Affective and Interpersonal Regulation), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Internet-Delivered Skills Training in Affective and Interpersonal Regulation (i-STAIR) for Individuals With Adverse Childhood Experiences and Subsyndromal Depression: A Pilot Study
Who cites it
11 citing papers in PubMed.
- Virtual Reality Relaxation for Reducing Aggression and Emotional Distress in At-Risk Adolescents in Israeli Residential Care: A Feasibility Randomized Clinical Trial.Aggressive behavior · 2026Trial
- Posterior cingulate cortex downregulation training using fMRI neurofeedback in adolescents with early life adversity exposure: a randomized, single-blind trial.Translational psychiatry · 2025Trial
- The effect of a mindfulness-based stress intervention on neurobiological and symptom measures in adolescents with early life stress: a randomized feasibility study.BMC complementary medicine and therapies · 2021Trial
- Recalibrating stress regulation through mindfulness: a framework for adapting interventions for ACE-affected populations.Frontiers in psychology · 2026Article
- Intergenerational continuity of adverse childhood experiences among Mexican-origin families: Examination of intra and extra-familial adversities.Family process · 2025Article
- The role of social support in reducing the long-term burden of cumulative childhood adversity on adulthood internalising disorder.Social psychiatry and psychiatric epidemiology · 2024Article
- The effect of cognitive reappraisal and early-life maternal care on neuroendocrine stress responses.Scientific reports · 2024Article
- Adverse childhood experiences and stress among oral health students: a descriptive correlational study.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2023Article
- Relationships Among Adverse and Benevolent Childhood Experiences, Emotion Dysregulation, and Psychopathology Symptoms.Adversity and resilience science · 2023Article
- The Efficacy of Targeted Mindfulness-Based Interventions for Improving Mental Health and Cognition Among Youth and Adults with ACE Histories: A Systematic Mixed Studies Review.Journal of child & adolescent trauma · 2022Article
- Health Care Access and Quality Among Children Exposed to Adversity: Implications for Universal Screening of Adverse Childhood Experiences.Maternal and child health journal · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Exposure to early life adversity (ELA) is a major public health crisis posing as a significant risk of immediate and sustained mental and physical health consequences. While a remarkable body of knowledge has been amassed showing psychological, cognitive, social, developmental, and neurobiological consequences of ELA exposure, little has been done to improve the long-term mental and physical health outcomes for youth exposed to ELA. Furthermore, neurobiological processes underlying poor outcomes in this population have been largely left out of prevention and intervention target efforts. In this review, we first describe ELA-related alterations across psychological and neurobiological systems in children and adolescents. Next, we describe existing evidence-based interventions targeting ELA-related outcomes. We then turn to experimental studies examining individual differences in mechanistic functioning consequent to ELA exposure, and strategies that target these mechanisms and modulate disrupted functioning. Finally, we highlight areas of future research that may be promising in engaging behavioral and neurobiological targets through novel preventive interventions or augmentation of existing interventions, thereby reducing negative mental and physical health outcomes later in life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.