ArticleCritical care explorations2021
Liver Dysfunction Associated With In-Hospital Mortality in Adult Extracorporeal Membrane Oxygenation Support.
Article in Critical care explorations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Biomarkers of multi-organ dysfunction in ECMO: prognostic signposts for palliative transitions.Frontiers in medicine · 2026Review
- Severe cholestasis in neonatal extracorporeal membrane oxygenation.The journal of extra-corporeal technology · 2025Article
- Predictive Value of Serial Model of End-Stage Liver Disease Score Determination in Patients with Postcardiotomy Extracorporeal Membrane Oxygenation.Journal of clinical medicine · 2024Article
- Prognostic Value of the AST/ALT Ratio versus Bilirubin in Patients with Cardiogenic Shock.Journal of clinical medicine · 2023Article
- ECMO as a bridge to cardiac surgery: stabilizing unstable patients for a definitive procedure.Indian journal of thoracic and cardiovascular surgery · 2023Review
- Predictors associated with mortality of veno-venous extracorporeal membrane oxygenation therapy.Journal of thoracic disease · 2023Article
- ECMO Retrieval Program: What Have We Learned So Far.Life (Basel, Switzerland) · 2023Article
- Serum Total Bilirubin With Hospital Survival in Adults During Extracorporeal Membrane Oxygenation.Frontiers in medicine · 2022Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracorporeal membrane oxygenator support is a powerful clinical tool that is currently enjoying a resurgence in popularity. Wider use of extracorporeal membrane oxygenator support is limited by its significant risk profile and extreme consumption of resources. This study examines the role of markers of liver dysfunction in predicting outcomes of adult patients requiring extracorporeal membrane oxygenator support.
designRetrospective review.
settingLarge extracorporeal membrane oxygenator center, Chicago, IL. PATIENTS: This study reports a single institution experience examining all adult patients for whom extracorporeal membrane oxygenator support was used over an 8-year period. Data were collected regarding patient demographics, details of extracorporeal membrane oxygenator support provided, laboratory data, and outcomes. Trends in liver function were examined for their ability to predict survival.
interventionExtracorporeal membrane oxygenator support, critical care. MEASUREMENTS AND MAIN
resultsMean age was 50 years (range, 19-82 yr). There were 86 male patients (56.6%) and 66 female patients (43.4%). Indications for initiation of extracorporeal membrane oxygenator support included cardiac 76 patients (50.0%), respiratory 48 patients (31.6%), extracorporeal cardiopulmonary resuscitation 21 patients (13.3%), and combined cardiac/respiratory seven patients (4.6%). Mean duration of extracorporeal membrane oxygenator support was 17 days (range 1-223 d) or median 8 days (interquartile range, 4-17 d). Overall, in-hospital mortality was 56% (86/152). Forty-five percent of adult patients (68/152) surpassed at least one of the following established liver dysfunction thresholds: total bilirubin greater than 15 mg/dL, aspartate aminotransferase greater than 20× upper limit of normal, and alanine aminotransferase greater than 20× upper limit of normal. The multivariable logistic analysis yielded three significant findings associated with in-hospital mortality: highest total bilirubin greater than 15 (adjusted odds ratio = 4.40; 95% CI, 1.19-21.87;
conclusionsIncreases in age, highest total bilirubin, and lactate all correlated with in-hospital mortality in multivariable analysis of patients requiring extracorporeal membrane oxygenator support.
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