Evidence map›Paper›PMID 34278287›Full record

ArticleEClinicalMedicine2021

Impact of COVID-19 on liver transplant recipients-A systematic review and meta-analysis.

Anand V Kulkarni, Harsh Vardhan Tevethia, Madhumita Premkumar, Juan Pablo Arab, Roberto Candia, Karan Kumar, Pramod Kumar, Mithun Sharma, Padaki Nagaraja Rao, Duvvuru Nageshwar Reddy

Open access · goldAbstract read
In one paragraph

Article in EClinicalMedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 75 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Observational
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  7. Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Article
  8. Observational
  9. Article
  10. Review
  11. Article
  12. Cirrhosis with COVID-19: Just another infection or something more to it?JGH open : an open access journal of gastroenterology and hepatology · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Effect of SARS-CoV-2 infection on the liver.World journal of virology · 2023
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Anand V KulkarniDepartment of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
Harsh Vardhan TevethiaDepartment of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
Madhumita PremkumarDepartment of Hepatology, PGIMER, Chandigarh, India.
Juan Pablo ArabDepartamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Roberto CandiaDepartamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago, Chile.
Karan KumarDepartment of Hepatology, Pacific Institute of Medical Sciences, Udaipur, India.
Pramod KumarDepartment of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
Mithun SharmaDepartment of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
Padaki Nagaraja RaoDepartment of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
Duvvuru Nageshwar ReddyDepartment of Hepatology, Asian Institute of Gastroenterology, Hyderabad, India.
Asian Institute of Gastroenterology · INPontificia Universidad Católica de Chile · CLPacific Dental College and Hospital · INPost Graduate Institute of Medical Education and Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunosuppression and comorbidities increase the risk of severe coronavirus disease-2019 (COVID-19) in solid organ transplant (SOT) recipients. The outcomes of COVID-19 in liver transplant (LT) recipients remain unclear. We aimed to analyse the outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in LT recipients.

methodsThe electronic databases were searched for articles published from 1 December 2019 to 20 May 2021 with MeSH terms COVID-19, SARS-CoV-2, and liver transplantation. Studies reporting outcomes in more than 10 LT recipients were included for analysis. LT vs non-LT patients with COVID-19 infection were compared for all-cause mortality, which was the primary outcome studied. We also evaluated the relation between the timing of COVID-19 infection post-LT (< one year vs > one year) and mortality.

findingsEighteen articles reporting 1,522 COVID-19 infected LT recipients were included for the systematic review. The mean age (standard deviation [SD]) was 60·38 (5·24) years, and 68·5% were men. The mean time (SD) to COVID-19 infection was 5·72 (1·75) years. Based on 17 studies (I

interpretationLT and non-LT patients with COVID-19 have a similar risk of adverse outcomes.

Indexed as

COVID-19liver transplantationliver transplant recipientsSARS-CoV-2solid organ transplantation

Identifiers

PMID34278287
PMCPMC8276632
OpenAlexW3183082842

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.