Evidence map›Paper›PMID 34278263›Full record

ArticleiScience2021

Linearization of genome sequence graphs revisited.

Anna Lisiecka, Norbert Dojer

Abstract read
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Anna LisieckaInstitute of Informatics, University of Warsaw, Banacha 2, 02-097 Warsaw, Poland.
Norbert DojerInstitute of Informatics, University of Warsaw, Banacha 2, 02-097 Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The need to include the genetic variation within a population into a reference genome led to the concept of a genome sequence graph. Nodes of such a graph are labeled with DNA sequences occurring in represented genomes. Due to double-stranded nature of DNA, each node may be oriented in one of two possible ways, resulting in marking one end of the labeling sequence as in-side and the other as out-side. Edges join pairs of sides and reflect adjacency between node sequences in genomes constituting the graph. Linearization of a sequence graph aims at orienting and ordering graph nodes in a way that makes it more efficient for visualization and further analysis, e.g. access and traversal. We propose a new linearization algorithm, called ALIBI - Algorithm for Linearization by Incremental graph BuIlding. The evaluation shows that ALIBI is computationally very efficient and generates high-quality results.

Indexed as

BioinformaticsComputer scienceGenomics

Identifiers

PMID34278263
PMCPMC8264155

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.