Evidence map›Paper›PMID 34278258›Full record

ArticleiScience2021

Reduced eIF4E function impairs B-cell leukemia without altering normal B-lymphocyte function.

Honyin Chiu, Roberta Buono, Leandra V Jackson, Lee-Or Herzog, Sharmila Mallya, Crystal S Conn, Davide Ruggero, David A Fruman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. MYC inhibitors in multiple myeloma.Cancer drug resistance (Alhambra, Calif.) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Honyin ChiuDepartment of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.
Roberta BuonoDepartment of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.
Leandra V JacksonDepartment of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.
Lee-Or HerzogDepartment of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.
Sharmila MallyaDepartment of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.
Crystal S ConnHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.
Davide RuggeroHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA.
David A FrumanDepartment of Molecular Biology & Biochemistry, University of California, Irvine, CA 92697, USA.
University of California, Irvine · USUniversity of California, San Francisco · US

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Mechanisms of regulated translation control in cancer and its therapeutic implicationsR35CA242986 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUGGERO, DAVIDE · 2019 to 2025
$6.4M
Immunology Research Training ProgramT32AI060573 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI PEARLMAN, ERIC · 2005 to 2020
$1.9M
Solving the elusive mechanism of rapamycin action in lymphocytesR21AI099656 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI FRUMAN, DAVID ALEXANDER · 2012 to 2013
$409k
NCI NIH HHS P30 CA062203NCI NIH HHS R35 CA242986NIAID NIH HHS R21 AI099656NIAID NIH HHS T32 AI060573
6 · The paper itself

Abstract

The cap-binding protein eukaryotic initiation factor 4E (eIF4E) promotes translation of mRNAs associated with proliferation and survival and is an attractive target for cancer therapeutics. Here, we used

Indexed as

cancercell biologymolecular biology

Identifiers

PMID34278258
PMCPMC8261676
OpenAlexW3167883004

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.