ReviewResearch and practice in thrombosis and haemostasis2021
Physical forces regulating hemostasis and thrombosis: Vessels, cells, and molecules in illustrated review.
Review in Research and practice in thrombosis and haemostasis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Protein force spectroscopy using magnetic tweezers: Slow and steady wins the race?Biophysical journal · 2026Review
- The Syk inhibitor BI 1002494 impairs thrombus infill in a murine femoral artery occlusion without affecting hemostasis.Blood vessels, thrombosis & hemostasis · 2025Article
- Uniaxial cyclic stretch regulates the expression of thrombomodulin and von Willebrand factor on endothelial cells.Blood vessels, thrombosis & hemostasis · 2025Article
- Review
- Observational
- Low hemoglobin causes hematoma expansion and poor intracerebral hemorrhage outcomes.bioRxiv : the preprint server for biology · 2024Article
- Fibroblast and myofibroblast activation in normal tissue repair and fibrosis.Nature reviews. Molecular cell biology · 2024Review
- Influence of Hematocrit Level and Integrin αCellular and molecular bioengineering · 2024Article
- Hemostasis Strategies and Recent Advances in Nanomaterials for Hemostasis.Molecules (Basel, Switzerland) · 2023Review
- Peripheral blood transcriptome analysis of patients with ovarian hyperstimulation syndrome through high-throughput sequencing.Reproductive and developmental medicine · 2023Article
- The roles of sub-micron and microscale roughness on shear-driven thrombosis on titanium alloy surfaces.Artificial organs · 2023Article
- Atomic Force Microscopy-Based Measurements of Retinal Microvessel Stiffness in Mice with Endothelial-Specific Deletion of CCN1.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Platelet-HIV: interactions and their implications.Platelets · 2022Article
- Physical forces regulating hemostasis and thrombosis: Vessels, cells, and molecules in illustrated review.Research and practice in thrombosis and haemostasis · 2021Review
- Emerging Microfluidic Approaches for Platelet Mechanobiology and Interplay With Circulatory Systems.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
This illustrated review focuses on the physical forces that regulate hemostasis and thrombosis. These phenomena span from the vessel to the cellular to the molecular scales. Blood is a complex fluid with a viscosity that varies with how fast it flows and the size of the vessel through which it flows. Blood flow imposes forces on the vessel wall and blood cells that dictates the kinetics, structure, and stability of thrombi. The mechanical properties of blood cells create a segmented flowing fluid whereby red blood cells concentrate in the vessel core and platelets marginate to the near-wall region. At the vessel wall, shear stresses are highest, which requires a repertoire of receptors with different bond kinetics to roll, tether, adhere, and activate on inflamed endothelium and extracellular matrices. As a thrombus grows and then contracts, forces regulate platelet aggregation as well as von Willebrand factor function and fibrin mechanics. Forces can also originate from platelets as they respond to the external forces and sense the stiffness of their local environment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.