Evidence map›Paper›PMID 34278164›Full record

ArticlePain reports

Analgesic effect of perineural local anesthetics, steroids, and conventional medical management for trauma and compression-related peripheral neuropathic pain: a retrospective cohort study.

Anuj Bhatia, Vera Bril, Richard T Brull, Anthony V Perruccio, Duminda N Wijeysundera, Johnny Lau, Rajiv Gandhi, Nizar Mahomed, Aileen M Davis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Tibial Nerve Block as Treatment of Chronic Foot Pain.Anesthesiology and pain medicine · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Anuj BhatiaDepartment of Anesthesiology and Pain Medicine and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-6292-8654
Vera BrilNeuromuscular Section, Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada.
Richard T BrullDepartment of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Anthony V PerruccioInstitute of Health Policy, Management & Evaluation, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-4389-0993
Duminda N WijeysunderaDepartment of Anesthesiology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-5897-8605
Johnny LauDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Rajiv GandhiDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Nizar MahomedDivision of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.
Aileen M DavisDepartment of Physical Therapy and Surgery, Graduate Department of Rehabilitation Science and Institute of Health Policy, Management and Evaluation and Institute of Medical Science, University of Toronto, Toronto, ON, Canada.
University of Toronto · CAUniversity Health Network · CASt. Michael's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTrauma and compression are common causes of peripheral neuropathic pain (NP) refractory to conventional medical management (CMM). The role of perineural interventions in relieving this type of pain is unclear.

objectivesThe objectives of this retrospective study were to determine the analgesic benefits of adding a combination of perineural local anesthetic and steroids (LA-S) to CMM compared with CMM alone in patients who had moderate-to-severe refractory NP after trauma to the ankle and the foot.

methodsHealth care records of 60 patients in exposed (3 injections of perineural LA-S at weekly intervals with CMM) and 60 in unexposed (CMM) cohorts were reviewed. Data on patient characteristics, pain, and mental and physical function were extracted at baseline and at the postintervention follow-up. Data were analyzed to evaluate analgesic benefit from the study interventions and the impact of baseline characteristics.

resultsPerineural LA-S with CMM cohort had lower pain numerical rating scale scores at 1 to 3 months after the intervention as compared to the CMM alone cohort (5.50 [interquartile range 4.00-7.00] and 7.00 [interquartile range 5.00-8.00], respectively;

conclusionPerineural local anesthetic and steroid injections do not confer an analgesic benefit for trauma- or compression-related peripheral NP.

Indexed as

CompressionPerineural local anesthetics and steroidsPeripheral neuropathic painTrauma

Identifiers

PMID34278164
PMCPMC8280075
OpenAlexW3178400162

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.