Evidence map›Paper›PMID 34278033›Full record

ArticleHeliyon2021

Alkaloidal extract from

Isaac Kyei-Barffour, Roselind Kyei Baah Kwarkoh, Ophelia Duke Arthur, Samuel Addo Akwetey, Desmond Omane Acheampong, Benjamin Aboagye, Augustine Suurinobah Brah, Isaac Kingsley Amponsah, Christian Kweku Adokoh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Isaac Kyei-BarffourDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.
Roselind Kyei Baah KwarkohDepartment of Physician Assistant Studies, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.
Ophelia Duke ArthurDepartment of Medical Laboratory and Diagnostics, Euracare Advance Diagnostic Center, Labone, Accra, Ghana.
Samuel Addo AkweteyDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.
Desmond Omane AcheampongDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.
Benjamin AboagyeDepartment of Forensic Sciences, School of Biological Sciences, University of Cape Coast, Ghana.
Augustine Suurinobah BrahDepartment of Biomedical Sciences, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, Ghana.
Isaac Kingsley AmponsahDepartment of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Unkrumah University of Science and Technology, Kumasi, Ghana.
Christian Kweku AdokohDepartment of Forensic Sciences, School of Biological Sciences, University of Cape Coast, Ghana.
University of Cape Coast · GHKwame Nkrumah University of Science and Technology · GH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIncrease in the prevalence of type-2 diabetes in Sub-Sahara Africa has created the need for robust treatment and management programs. However, an effective diabetes management program requires a high annual budget that most countries in this region cannot afford. That said, various plants and plant products in this region have either been confirmed and/or ethnopharmacologically used for the management of type-2 diabetes.

aimTo investigate the antidiabetic and insulin secretory effects of an alkaloidal extract derived from MATERIALS AND

methodsAlkaloidal extract was prepared from leaves of

resultsZZAE improved glucose kinetics curve in normoglycemic (p < 0.001) and experimental diabetic rats (p < 0.05) compared to the model. ZZAE (100 and 150 mg/kg) restored islets population, and improved kidney, and liver, histoarchitecture. ZZAE (150 mg/kg) improved post-treatment serum insulin levels compared to the model group (p < 0.001) and the Chlorpropamide group (p < 0.05). ZZAE also restored glycogen synthesis in skeletal muscles of experimental diabetic rats and stimulated insulin secretion in pancreatic islets of Langerhans isolated from normoglycemic rats.

conclusionThese results showed that ZZAE has active alkaloids that can be explored for diabetes management.

Indexed as

Alkaloidal extractAntidiabeticGlucose toleranceGlycogen synthesisHistoarchitecture

Identifiers

PMID34278033
PMCPMC8267442
OpenAlexW3176093941

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.