Evidence map›Paper›PMID 34277969›Full record

ArticleEndocrinology, diabetes & metabolism2021

Treatment of patients with Graves' disease in Sweden compared to international surveys of an 'index patient'.

Gabriel Sjölin, Kristina Byström, Mats Holmberg, Ove Törring, Selwan Khamisi, Jan Calissendorff, Mikael Lantz, Bengt Hallengren, Helena Filipsson Nyström, Tereza Planck and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, diabetes & metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Long-Term Outcome of Graves' Disease: A Gender Perspective.Women's health reports (New Rochelle, N.Y.) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Gabriel SjölinFaculty of Medicine and Health Örebro University Hospital Örebro Sweden.ORCID 0000-0003-2367-8503
Kristina ByströmDepartment of Medicine Örebro University and University Hospital Örebro Sweden.
Mats HolmbergInstitute of Medicine Sahlgrenska Academy University of Gothenburg Göteborg Sweden.
Ove TörringInstitution for Clinical Science and Education Karolinska Institutet Stockholm Sweden.
Selwan KhamisiDepartment of Endocrinology Uppsala University Hospital Uppsala Sweden.
Jan CalissendorffDepartment of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden.
Mikael LantzDepartment of Endocrinology Skåne University Hospital Malmö Sweden.
Bengt HallengrenDepartment of Endocrinology Skåne University Hospital Malmö Sweden.
Helena Filipsson NyströmInstitute of Medicine Sahlgrenska Academy University of Gothenburg Göteborg Sweden.
Tereza PlanckDepartment of Endocrinology Skåne University Hospital Malmö Sweden.
Göran WallinFaculty of Medicine and Health Örebro University Hospital Örebro Sweden.
Lund University · SEKarolinska Institutet · SEKarolinska University Hospital · SEÖrebro University Hospital · SESahlgrenska University Hospital · SEUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe treatment strategies for a 42-year-old female index patient with moderate Graves' disease (GD) vary according to several international surveys. The important question whether surveys of treatment preferences in theoretical patient cases also match how real patients are treated has not yet been addressed. MATERIALS AND

methodsFrom a Swedish cohort of 1186 GD patients (TT-12 cohort), 27 women were identified using the same criteria as from the index patient surveys from the European and American Thyroid Associations. This 'index patient cohort' was age 40-45, otherwise healthy female, with two children and uncomplicated GD. The applied first-line treatment of the patients in the index cohort, together with its variations, was compared with the treatment preferences according to international surveys. A comparison with the TT-12 cohort was also performed.

resultsIn the 'Index cohort', 77.8% were treated with antithyroid drugs (ATD), and 22.2% were treated with radioiodine (

conclusionThe treatment choice in an index patient in Sweden seems in line with European practice, where ATD is the preferred first choice. This differs compared to US and North African survey intentions, where

Indexed as

Graves DiseaseIodine RadioisotopesAdultAgedAntithyroid AgentsChildFemaleHumansMaleMiddle AgedSwedenThyroidectomyUnited StatesYoung AdultAntithyroid AgentsIodine Radioisotopesantithyroid drugsGraves’ diseasehyperthyroidismindex patientinternational surveyslong‐term follow‐upradioactive iodinethyroidectomytreatment options

Identifiers

PMID34277969
PMCPMC8279596
OpenAlexW3139181041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.