Evidence map›Paper›PMID 34277899›Full record

ArticleRegenerative therapy2021

Prenatal enzyme replacement therapy for

Akihiro Hasegawa, Aki Nakamura-Takahashi, Masataka Kasahara, Nana Saso, Sonoko Narisawa, José Luis Millán, Osamu Samura, Haruhiko Sago, Aikou Okamoto, Akihiro Umezawa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Akihiro HasegawaCenter for Regenerative Medicine, National Center for Child Health and Development Research Institute, Tokyo, Japan.
Aki Nakamura-TakahashiDepartment of Pharmacology, Tokyo Dental College, Tokyo, Japan.
Masataka KasaharaDepartment of Pharmacology, Tokyo Dental College, Tokyo, Japan.
Nana SasoCenter for Regenerative Medicine, National Center for Child Health and Development Research Institute, Tokyo, Japan.
Sonoko NarisawaSanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
José Luis MillánSanford Children's Health Research Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Osamu SamuraDepartment of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
Haruhiko SagoCenter for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development, Tokyo, Japan.
Aikou OkamotoDepartment of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
Akihiro UmezawaCenter for Regenerative Medicine, National Center for Child Health and Development Research Institute, Tokyo, Japan.
Jikei University School of Medicine · JPNational Center For Child Health and Development · JPSanford Burnham Prebys Medical Discovery Institute · USTokyo Dental College · JP

Funding

MOLECULAR PATHOGENESIS/TREATMENT OF HYPOPHOSPHATASIAR01DE012889 · NIDCR · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI MILLAN, JOSE LUIS · 1999 to 2020
$9.2M
NIDCR NIH HHS R01 DE012889
6 · The paper itself

Abstract

Hypophosphatasia (HPP) is a congenital skeletal disease. Impairment of bone mineralization and seizures are due to a deficiency of tissue-nonspecific alkaline phosphatase (TNAP). Enzyme replacement therapy (ERT) is available as a highly successful treatment for pediatric-onset HPP. However, the potential for prenatal ERT has not been fully investigated to date. In this study, we assessed outcomes and maternal safety using a combinational approach with prenatal and postnatal administration of recombinant TNAP in

Indexed as

Alkaline phosphataseALP, alkaline phosphataseCalcificationEnzyme replacement therapyERT, enzyme replacement therapyFetal therapyHPP, hypophosphatasiaHypophosphatasiaPLP, pyridoxal 5′-phosphatePPi, inorganic pyrophosphatePrenatal diagnosisTNAP, tissue-nonspecific alkaline phosphatase

Identifiers

PMID34277899
PMCPMC8267436
OpenAlexW3182975559

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.