Evidence map›Paper›PMID 34277818›Full record

ArticleAnnals of translational medicine2021

Up-regulated long noncoding RNA AC007128.1 and its genetic polymorphisms associated with Tuberculosis susceptibility.

Hong Yan, Guoye Liu, Yuan Liang, Wei Wu, Rui Xia, Lin Jiao, Han Shen, Zhijun Jia, Qian Wang, Zhiqiang Wang and 4 more

Open access · diamondAbstract read
In one paragraph

Article in Annals of translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. LncRNAAnnals of medicine · 2025
    Article
  4. Long non-coding RNA transcripts inNon-coding RNA research · 2025
    Review
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Hong YanDepartment of Clinical Laboratory Medicine, the First Medical Center, Chinese PLA General Hospital, Beijing, China.
Guoye LiuDepartment of Laboratory Medicine, Affiliated Brain Hospital of Nanjing Medical University (Chest Branch), Nanjing, China.
Yuan LiangThe Affiliated Cancer Hospital & Hepatobiliary Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, China.
Wei WuDepartment of Bioinformatics, Nanjing Medical University, Nanjing, China.
Rui XiaDepartment of Laboratory Medicine, Affiliated Brain Hospital of Nanjing Medical University (Chest Branch), Nanjing, China.
Lin JiaoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Han ShenDepartment of Clinical Laboratory, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Zhijun JiaDepartment of Nuclear Medicine, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
Qian WangDepartment of Laboratory Medicine, Affiliated Brain Hospital of Nanjing Medical University (Chest Branch), Nanjing, China.
Zhiqiang WangDepartment of Laboratory Medicine, Affiliated Brain Hospital of Nanjing Medical University (Chest Branch), Nanjing, China.
Yi KongDepartment of Clinical Laboratory Medicine, the First Medical Center, Chinese PLA General Hospital, Beijing, China.
Binwu YingDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Hualiang WangDepartment of Molecular Biology, Shanghai Centre for Clinical Laboratory, Shanghai, China.
Chengbin WangDepartment of Clinical Laboratory Medicine, the First Medical Center, Chinese PLA General Hospital, Beijing, China.
Nanjing Medical University · CNChinese PLA General Hospital · CNNanjing Brain Hospital · CNNanjing Drum Tower Hospital · CNWest China Hospital of Sichuan University · CNSecond Affiliated Hospital of Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis (TB) remains a major public health problem. Long non-coding RNAs (lncRNAs) are important regulators of gene expression. In this study, we explored the association between the expression of lncRNA AC007128.1 and TB susceptibility.

methodsThree single-nucleotide polymorphisms (SNPs) (rs12333784, rs6463794, and rs720964) of lncRNA AC007128.1 were selected using the 1000 Genomes Project database and offline software Haploview V4.2, and were genotyped by a customized 2×48-Plex SNPscan™ Kit.

resultsWe identified two differentially expressed lncRNA including AC007128.1 and AP001065.3 in comparisons of expression profiles between ATB

conclusionsOur findings show lncRNA AC007128.1 can be regarded as biomarkers discriminating between ATB and LTBI and may also be a diagnostic biomarker for LBTI. These findings may aid clinical decision making in the management of TB.

Indexed as

AC007128.1biomarkergenetic susceptibilitysingle nucleotide polymorphisms (SNPs)tuberculosis infection

Identifiers

PMID34277818
PMCPMC8267308
OpenAlexW3175676191

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.