Evidence map›Paper›PMID 34277471›Full record

ArticleFrontiers in cellular and infection microbiology2021

Differential Response of Oral Mucosal and Gingival Cells to

Ulrike Redanz, Sylvio Redanz, Puthalayai Treerat, Sivaraman Prakasam, Li-Jung Lin, Justin Merritt, Jens Kreth

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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  5. Immunostimulatory effects ofInfection and immunity · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Ulrike RedanzDepartment of Restorative Dentistry, School of Dentistry, Oregon Health & Science University, Portland, OR, United States.
Sylvio RedanzDepartment of Restorative Dentistry, School of Dentistry, Oregon Health & Science University, Portland, OR, United States.
Puthalayai TreeratDepartment of Restorative Dentistry, School of Dentistry, Oregon Health & Science University, Portland, OR, United States.
Sivaraman PrakasamDepartment of Periodontology, School of Dentistry, Oregon Health & Science University, Portland, OR, United States.
Li-Jung LinDepartment of Translational Rheumatology and Immunology, Institute for Musculoskeletal Medicine, University of Münster, Münster, Germany.
Justin MerrittDepartment of Restorative Dentistry, School of Dentistry, Oregon Health & Science University, Portland, OR, United States.
Jens KrethDepartment of Restorative Dentistry, School of Dentistry, Oregon Health & Science University, Portland, OR, United States.
Oregon Health & Science University · USUniversity of Münster · DE

Funding

Advancing studies of polymicrobial diseases via streptococcal geneticsR35DE028252 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI MERRITT, JUSTIN · 2018 to 2025
$7.8M
Pyruvate oxidase: a molecular determinant of commensalism among the oral microbiomeR01DE029492 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2024
$2.5M
Pyruvate oxidase determines ecological fitness of oral streptococciR01DE021726 · NIDCR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI KRETH, JENS · 2014 to 2018
$1.9M
Streptococcal secretion of pyruvate - a novel antioxidant strategy in the oral biofilmR21DE029612 · NIDCR · OREGON HEALTH & SCIENCE UNIVERSITY · PI KRETH, JENS · 2020 to 2021
$424k
NIDCR NIH HHS R01 DE021726NIDCR NIH HHS R01 DE029492NIDCR NIH HHS R21 DE029612NIDCR NIH HHS R35 DE028252
6 · The paper itself

Abstract

Polymicrobial interactions with oral mucosal surfaces determine the health status of the host. While a homeostatic balance provides protection from oral disease, a dysbiotic polymicrobial community promotes tissue destruction and chronic oral diseases. How polymicrobial communities transition from a homeostatic to a dysbiotic state is an understudied process. Thus, we were interested to investigate this ecological transition by focusing on biofilm communities containing high abundance commensal species and low abundance pathobionts to characterize the host-microbiome interactions occurring during oral health. To this end, a multispecies biofilm model was examined using the commensal species

Indexed as

Porphyromonas gingivalisStreptococcus sanguisBiofilmsCorynebacteriumHumansCorynebacteriumcytokineimmune responseoral biofilmStreptococcus

Identifiers

PMID34277471
PMCPMC8282179
OpenAlexW3184275344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.