Evidence map›Paper›PMID 34277467›Full record

ArticleFrontiers in cellular and infection microbiology2021

Trehalose-Induced Remodelling of the Human Microbiota Affects

Anthony M Buckley, Ines B Moura, Norie Arai, William Spittal, Emma Clark, Yoshihiro Nishida, Hannah C Harris, Karen Bentley, Georgina Davis, Dapeng Wang and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trehalose's untapped mechanisms in alzheimer's: gut-brain-autophagy signalling beyond the usual targets.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026
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  6. The Effects of Cocoons ofCurrent therapeutic research, clinical and experimental · 2025
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  8. Biological Properties ofAntioxidants (Basel, Switzerland) · 2024
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  15. Review
  16. Non-ToxigenicAntibiotics (Basel, Switzerland) · 2023
    Article
  17. Review
  18. Article
  19. Review
  20. Wolf in Sheep's Clothing:Microorganisms · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Anthony M BuckleyHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Ines B MouraHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Norie AraiR&D Division, Hayashibara Co. Ltd./NAGASE Group, Okayama, Japan.
William SpittalHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Emma ClarkHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Yoshihiro NishidaR&D Division, Hayashibara Co. Ltd./NAGASE Group, Okayama, Japan.
Hannah C HarrisHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Karen BentleyHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Georgina DavisHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Dapeng WangLeedsOmics, University of Leeds, Leeds, United Kingdom.
Suparna MitraHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
Takanobu HigashiyamaR&D Division, Hayashibara Co. Ltd./NAGASE Group, Okayama, Japan.
Mark H WilcoxHealthcare Associated Infection Research Group, Molecular Gastroenterology, Leeds Institute of Medical Research, University of Leeds, Leeds, United Kingdom.
University of Leeds · GBHayashibara (Japan) · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Within the human intestinal tract, dietary, microbial- and host-derived compounds are used as signals by many pathogenic organisms, including

Indexed as

Clostridioides difficileClostridium InfectionsMicrobiotaAnti-Bacterial AgentsClostridioidesHumansPilot ProjectsTrehaloseAnti-Bacterial AgentsTrehaloseClostridium difficilehuman microbiotain vitro gut modelmicrobial competitiontrehalose

Identifiers

PMID34277467
PMCPMC8284250
OpenAlexW3183559588

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.