Evidence map›Paper›PMID 34277463›Full record

ArticleFrontiers in cellular and infection microbiology2021

Differences in Manifestations and Gut Microbiota Composition Between Patients With Different Henoch-Schonlein Purpura Phenotypes.

Yuanzhen Zhang, Guizhi Xia, Xiaojing Nie, Yugui Zeng, Yi Chen, Yifang Qian, Guangming Chen, Jun Huang, Chengfeng Wang, Chuanyin Zhang and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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  13. [Features of intestinal flora in children with food protein-induced proctocolitis based on high-throughput sequencing].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 1 country.

Yuanzhen ZhangDepartment of Pediatrics, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, China.
Guizhi XiaDepartment of Pediatrics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
Xiaojing NieDepartment of Pediatrics, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, China.
Yugui ZengDepartment of Pediatrics, Affiliated Dongfang Hospital, Xiamen University, Fuzhou, China.
Yi ChenDepartment of Pediatrics, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China.
Yifang QianDepartment of Pediatrics, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, China.
Guangming ChenDepartment of Pediatrics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
Jun HuangDepartment of Pediatrics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
Chengfeng WangDepartment of Pediatrics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
Chuanyin ZhangDepartment of Pediatrics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
Xiaoli HuangDepartment of Pediatrics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
Yuen YangDepartment of Pediatrics, The 900th Hospital of Joint Logistic Support Force, Fuzhou, China.
Xiaojian QiuDepartment of Pediatrics, The Fujian Provincial Maternity and Children's Hospital, Fuzhou, China.
Fang YangDepartment of Pediatrics, Fujian Provincial Hospital, Fuzhou, China.
Jie ChenDepartment of Pediatrics, Fujian Provincial Hospital, Fuzhou, China.
Jun HuDepartment of Pediatrics, Fujian Medical University Union Hospital, Fuzhou, China.
Fujian Medical University · CNFujian Provincial Hospital · CNXiamen University · CNUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gut microbiota plays an important role in the pathogenesis of immune-mediated diseases. However, the complex pathogenesis of Henoch-Schonlein Purpura (HSP) remains elusive. This study aimed to characterize the gut microbiota in HSP patients and explore the potential association between gut microbiota composition and phenotypic changes in HSP. Methods: 16SrRNA gene sequencing and bioinformatic analyses were performed using total DNA extracted from the fecal microbiota of 34 children with HSP, including 18 primary cases, 16 recurrent cases, and 23 healthy children. Results: The diversity indexes showed significant differences in the microbial community among the primary HSP groups, the recurrent HSP group and healthy controls. The abundance of Conclusions: The gut microbiota of children with HSP was different from that of healthy children. The genus

Indexed as

Gastrointestinal MicrobiomeIgA VasculitisMicrobiotaChildFecesHumansPhenotypeautoimmune diseasegut microbiotaHenoch-Schonlein Purpuramanifestationsphenotypes

Identifiers

PMID34277463
PMCPMC8281929
OpenAlexW3184118760

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.