ArticleFrontiers in oncology2021
Development and Validation of a Prognostic Nomogram for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed.
- Development of a prognostic nomogram for colorectal cancer with peritoneal metastasis: a SEER database analysis.Translational cancer research · 2026Article
- Construction of a nomogram-based risk prediction model for depressive symptoms in middle-aged and young breast cancer patients.World journal of clinical oncology · 2025Article
- Development and Validation of Platelet-Index Based Colorectal Cancer Survival Prognostic Nomogram.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in the Management of Colorectal Cancer with Peritoneal Metastasis: A Single-Center Cohort Study.Medicina (Kaunas, Lithuania) · 2024Article
- A prediction nomogram for perineural invasion in colorectal cancer patients: a retrospective study.BMC surgery · 2024Article
- Cytoreductive surgery for synchronous and metachronous colorectal peritoneal dissemination: Japanese P classification and peritoneal cancer index.Annals of gastroenterological surgery · 2024Article
- Prognostic value of normal levels of preoperative tumor markers in colorectal cancer.Scientific reports · 2023Article
- Development and validation of a nomogram for predicting metachronous peritoneal metastasis in colorectal cancer: A retrospective study.World journal of gastrointestinal oncology · 2023Article
- Effect ofGastroenterology report · 2023Article
- Article
- Lobaplatin hyperthermic intraperitoneal chemotherapy plus cytoreduction and rechallenge using cetuximab for wild-type RAS peritoneal metastatic colon cancer: a case report and literature review.BMC gastroenterology · 2022Review
- A nomogram to predict risk factors of frequent defecation early after ileostomy reversal for rectal cancer patients.Annals of translational medicine · 2021Article
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8 authors.
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Abstract
purposeSynchronous peritoneal metastasis (S-PM) is considered a poor prognostic factor for colorectal cancer (CRC) and there is no nomogram to predict the survival of these patients. In this study, we aimed to use a multicenter data to identify the factors associated with S-PM of CRC to construct a nomogram for predicting the overall survival (OS) of these patients.
methodsCRC patients with S-PM from two medical centers were enrolled between September 2007 and June 2017. Multivariate analysis was used to identify independent factors associated with OS for the nomogram to predict the 1-, 2-, and 3-year OS rates in the development group. The concordance index (C-index), calibration plot, relative operating characteristic (ROC) curve with area under the curve (AUC) were calculated to evaluate the performance of the nomogram in both the development and an external validation group.
results277 CRC patients with S-PM in the development group and 68 patients in the validation group were eligible for this study. In multivariate analysis of development group, age, carbohydrate antigen 19-9 (CA19-9), carbohydrate antigen 125 (CA125), cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC), and chemotherapy were independent variables for OS, based on which the nomogram was built. The C-index of the nomogram in the development and validation group was 0.701 (95% Cl, 0.666-0.736) and 0.716 (95% Cl, 0.622-0.810); demonstrating good discriminative ability. The calibration plots showed satisfactory consistency between actual observation and nomogram-predicted OS probabilities in the development and external validation group. The nomogram showed good predictive accuracy for 1-, 2-, and 3-year OS rates in both groups with AUC >0.70. An online dynamic webserver was also developed for increasing the ease of the nomogram.
conclusionsWe developed and validated a predictive nomogram with good discriminative and high accuracy to predict the OS in CRC patients with S-PM.
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