Evidence map›Paper›PMID 34277358›Full record

ArticleToxicology reports2021

Subchronic neurotoxicity of diazinon in albino mice: Impact of oxidative stress, AChE activity, and gene expression disturbances in the cerebral cortex and hippocampus on mood, spatial learning, and memory function.

Asieh Karimani, Nasrin Ramezani, Amir Afkhami Goli, Mohammad Hossein Nazem Shirazi, Hosein Nourani, Amir Moghaddam Jafari

Open access · goldAbstract read
In one paragraph

Article in Toxicology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Asieh KarimaniDepartment of Toxicology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Nasrin RamezaniDepartment of Toxicology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Amir Afkhami GoliDepartment of Toxicology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Mohammad Hossein Nazem ShiraziCentral Veterinary Laboratory, Veterinary Head Office of Khorasan Razavi, Mashhad, Iran.
Hosein NouraniDepartment of Pathology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Amir Moghaddam JafariDepartment of Toxicology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran.
Ferdowsi University of Mashhad · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diazinon (DZN) with prominent neurotoxic effects perturbs CNS function via multiple mechanisms. This investigation intends to explore mood, spatial learning, and memory dysfunction, acetylcholine esterase (AChE) activity, and neurodegeneration-related gene expression in the cortex and hippocampus regions of mice exposed to DZN for 63 consecutive days (subchronic exposure). Adult male albino mice were orally given sublethal DZN (DZN

Indexed as

Ach, acetylcholineAChE, acetylcholine esteraseAD, Alzheimer’s diseaseCerebral cortexCOX-2, cyclooxygenase-2CX, cerebral cortexDiazinonDZN, diazinonDZO, diazoxonFRAP, ferric reducing antioxidant powerFST, forced swim testGABA, ϒ-aminobutyric acidGAD65, glutamate decarboxylase 65HippocampusHP, hippocampusLD50, lethal dose 50MB, marble burying testMDA, malondialdehydeMemoryMWM, Morris water maze testNeurodegenerative diseasesNOAEL, no-observed-adverse-effect levelOps, organophosphatesPD, Parkinson’s diseaseqRT-PCR, quantitative reverse transcription-polymerase chain reactionRNS, reactive nitrogen speciesROS, reactive oxygen speciesSEM, standard error of the meanSpatial learningSYP, synaptophysinVAChT, vesicular acetylcholine transferase

Identifiers

PMID34277358
PMCPMC8261896
OpenAlexW3175033550

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.