Evidence map›Paper›PMID 34277150›Full record

ArticlePeerJ2021

NMDAR in bladder smooth muscle is not a pharmacotherapy target for overactive bladder in mice.

Xiang Xie, Chuang Luo, Jia Yu Liang, Run Huang, Jia Li Yang, Linlong Li, YangYang Li, Hongming Xing, Huan Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Xiang XiePublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Chuang LuoPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Jia Yu LiangPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Run HuangPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Jia Li YangPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Linlong LiPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
YangYang LiPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Hongming XingPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Huan ChenPublic Center of Experimental Technology and The School of Basic Medical Sciences, Southwest Medical University, Luzhou, Sichuan, China.
Southwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overactive bladder (OAB) is a common condition that affects a significant patient population. The N-methyl-D-aspartate receptor (NMDAR) has a role in developing bladder overactivity, pharmacological inhibition of which inhibits bladder overactivity. The common pathogenesis of OAB involves bladder smooth muscle (BSM) overactivity. In this study, a smooth muscle-specific NMDAR knockout (

Indexed as

Bladder smooth muscleCyclophosphamideCystometryMK801N-methyl-D-aspartate receptorOveractive bladderVoiding spot assay

Identifiers

PMID34277150
PMCPMC8272467
OpenAlexW3179137909

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.