Evidence map›Paper›PMID 34277146›Full record

ArticlePeerJ2021

Effects of exercise training with blood flow restriction on vascular function in adults: a systematic review and meta-analysis.

Elisio A Pereira-Neto, Hayley Lewthwaite, Terry Boyle, Kylie Johnston, Hunter Bennett, Marie T Williams

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06596304 (Comparing Macro- and Microvascular Responses to Acute Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults), which is not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06596304 narecruitingnot on this mapstarted 2024, after this paper: background citation

Comparing Macro- and Microvascular Responses to Acute Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults: a Parallel Group Crossover Randomized Trial

TypeinterventionalSponsorEgas Moniz - Cooperativa de Ensino Superior, CRLRan2024 to 2025Enrolled52ConditionsAgeing, Blood Flow RestrictionArmsLow intensity-resistance training with lower limb blood flow restriction, High Intensity Resistance Training
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elisio A Pereira-NetoInnovation, IMPlementation And Clinical Translation in Health (IIMPACT), University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-4943-418X
Hayley LewthwaiteInnovation, IMPlementation And Clinical Translation in Health (IIMPACT), University of South Australia, Adelaide, South Australia, Australia.
Terry BoyleAllied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0001-6741-330X
Kylie JohnstonInnovation, IMPlementation And Clinical Translation in Health (IIMPACT), University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-4436-3108
Hunter BennettAllied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-8541-9104
Marie T WilliamsInnovation, IMPlementation And Clinical Translation in Health (IIMPACT), University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-0473-5157

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBlood flow restricted exercise (BFRE) improves physical fitness, with theorized positive effects on vascular function. This systematic review and meta-analysis aimed to report (1) the effects of BFRE on vascular function in adults with or without chronic health conditions, and (2) adverse events and adherence reported for BFRE. METHODOLOGY: Five electronic databases were searched by two researchers independently to identify studies reporting vascular outcomes following BFRE in adults with and without chronic conditions. When sufficient data were provided, meta-analysis and exploratory meta-regression were performed.

resultsTwenty-six studies were included in the review (total participants

conclusionThere is limited evidence, predominantly available in healthy young adults, on the effect of BFRE on vascular function. Signals pointing to effect of specific dynamic resistance exercise protocols with blood flow restriction (≥4 weeks with exercises for the upper and lower limbs) on endothelial function warrant further investigation.

Indexed as

ExerciseIschemiaVascular endotheliumVascular occlusionVascular stiffness

Identifiers

PMID34277146
PMCPMC8272459

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.