Evidence map›Paper›PMID 34277141›Full record

SynthesisTremor and other hyperkinetic movements (New York, N.Y.)2021

How Common is Essential Tremor? Update on the Worldwide Prevalence of Essential Tremor.

Elan D Louis, Morgan McCreary

Abstract readMeta-Analysis
In one paragraph

Synthesis in Tremor and other hyperkinetic movements (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 146 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
146citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

146 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Diagnostic Accuracy of the Archimedes Spiral Test for Essential Tremor: A Meta-Analysis.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Pooled it
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  7. Essential Tremor Suppression with a Novel Anti-Tremor Orthosis: A Randomized Crossover Trial.Movement disorders : official journal of the Movement Disorder Society · 2025
    Trial
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  11. Review
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86 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elan D LouisDepartment of Neurology, University of Texas Southwestern, Dallas, TX, USA.ORCID 0000-0003-2062-362X
Morgan McCrearyDepartment of Neurology, University of Texas Southwestern, Dallas, TX, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Clinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1M
Environmental Epidemiology of Essential TremorR01NS094607 · NINDS · YALE UNIVERSITY · PI LOUIS, ELAN D · 2016 to 2020
$3.9M
PATHOLOG-OMICS - ESSENTIAL TREMOR IN THE BROADER CONTEXT OF NEURODEGENERATIONR01NS088257 · NINDS · YALE UNIVERSITY · PI FAUST, PHYLLIS L, LOUIS, ELAN D · 2015 to 2019
$3.3M
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R01 NS086736NINDS NIH HHS R01 NS088257NINDS NIH HHS R01 NS094607
6 · The paper itself

Abstract

Background: Essential tremor (ET) is among the most prevalent movement disorders. Comprehensive reviews of disease prevalence were published in 1998 and 2010 but not since then. We reviewed the prevalence of ET in population-based epidemiological studies, derived a precise summary estimate of prevalence from these studies, and examined differences in prevalence across studies. We used two methods: a descriptive-analytical approach and a meta-analysis. Methods: A PUBMED search yielded 14 published papers since the 2010 review. Results: There were 42 population-based prevalence studies (23 countries and 6 continents). In a meta-analysis, pooled prevalence (all ages) = 1.33%, with statistically significant heterogeneity across studies (I Discussion: Precise prevalence estimates are important because they form the numerical basis for public health initiatives and offer clues about underlying biological factors of mechanistic importance. The prevalence of ET among those age ≥ 65 is similar to that reported for Alzheimer's disease in elders, suggesting that ET may be the most common neurodegenerative disease.

Indexed as

Essential TremorNeurodegenerative DiseasesAgedHumansInfantInfant, NewbornPrevalencedefinitionepidemiologyEssential tremorprevalence

Identifiers

PMID34277141
PMCPMC8269764

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.